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phosphate cytidylyltransferase 2, ethanolamine

Summary

Gene Symbol

PCYT2

Aliases

CTP:phosphoethanolamine cytidylyltransferase
ET
ethanolamine-phosphate cytidylyltransferase:
phosphorylethanolamine transferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

5833

HGNC

8756

KEGG Gene ID

hsa:5833

PubChem

5833

Alliance of Genome Resources

HGNC:8756

Annotation

Keyword

3D-structure
Alternative splicing
Disease variant
Hereditary spastic paraplegia
Lipid biosynthesis
Nucleotidyltransferase
Phospholipid biosynthesis
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q99447	CTP:phosphoethanolamine cytidylyltransferase Phosphorylethanolamine transferase
I3L1R7	CTP:phosphoethanolamine cytidylyltransferase
B3KSC8	CTP:phosphoethanolamine cytidylyltransferase
B7Z4W6	CTP:phosphoethanolamine cytidylyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
phospholipid biosynthetic process		9083101
phosphatidylethanolamine biosynthetic process	IBA IEA IMP	31637422

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytoplasm	IBA
endoplasmic reticulum membrane
cellular_component	ND

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
ethanolamine-phosphate cytidylyltransferase activity	IBA IMP TAS	31637422 9083101
protein binding	IPI	32296183 32814053

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

cytidylyltransferase activity [inference]

ethanolamine-phosphate cytidylyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000185813

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:24592

H⁺ + CTP + phosphoethanolamine

diphosphate + CDP-ethanolamine

Enzyme

2.7.7.14

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 66 in total

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DO ID	Disease Name	Source
DOID:0050886	Troyer syndrome	DisGeNET
DOID:0060245	Mast syndrome	DisGeNET
DOID:0060246	MASA syndrome	DisGeNET
DOID:0060491	SPOAN syndrome	DisGeNET
DOID:0080067	Charcot-Marie-Tooth disease type 5	DisGeNET
DOID:0110763	hereditary spastic paraplegia 10	DisGeNET
DOID:0110764	hereditary spastic paraplegia 11	DisGeNET
DOID:0110765	hereditary spastic paraplegia 12	DisGeNET
DOID:0110766	hereditary spastic paraplegia 13	DisGeNET
DOID:0110767	hereditary spastic paraplegia 14	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 12 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000639	Nystagmus
HP:0000648	Optic atrophy
HP:0000750	Delayed speech and language development
HP:0001249	Intellectual disability
HP:0001257	Spasticity
HP:0001347	Hyperreflexia
HP:0002059	Cerebral atrophy
HP:0002376	Developmental regression
HP:0003487	Babinski sign

Displaying 1 entry
Disease ID	Disease Name
OMIM:618770	spastic paraplegia 82, autosomal recessive

PubChem Disease

MedGen Diseases

Spastic paraplegia 82, autosomal recessive

OMIM Phenotypes

SPASTIC PARAPLEGIA 82, AUTOSOMAL RECESSIVE; SPG82

KEGG Diseases

Hereditary spastic paraplegia

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001012
Gene Name: phosphate cytidylyltransferase 2, ethanolamine

Ortholog

Displaying entries **1 - 10** of 83 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	171770	WB:WBGene00021352
Caenorhabditis elegans	181047	WB:WBGene00016531
Drosophila melanogaster	34716	FB:FBgn0032482
Callorhinchus milii	103175582		CALMI08323
Latimeria chalumnae	102358376		LATCH18298
Danio rerio	450016	ZFIN:ZDB-GENE-041010-132
Ictalurus punctatus	108277112		ICTPU25121
Electrophorus electricus	113575306		ELEEL15742
Esox lucius	105013038		ESOLU31802
Salmo trutta	115171807		SALTR94344

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Other Information

Tools

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Summary

External Links

Annotation

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements