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Guidelines

MIRAGE

glycogen phosphorylase B

Summary

Gene Symbol

PYGB

Aliases

glycogen phosphorylase, brain form

Organism

Homo sapiens (human)

External Links

NCBI Gene

5834

HGNC

9723

KEGG Gene ID

hsa:5834

PubChem

5834

Alliance of Genome Resources

HGNC:9723

Annotation

Keyword

3D-structure
Acetylation
Allosteric enzyme
Direct protein sequencing
Glycogen metabolism
Glycosyltransferase
Phosphoprotein
Pyridoxal phosphate
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P11216

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
glycogen catabolic process	NAS	3346228
glycogen catabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process [inference]

glycogen catabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process [inference]

glycogen catabolic process

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process [inference]

glycogen catabolic process

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process [inference]

glycogen catabolic process

glucan catabolic process [inference]

glycogen catabolic process

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process [inference]

glycogen catabolic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
cytoplasm	IDA	10638593
cytoplasm	IBA
membrane	HDA	19946888
azurophil granule lumen	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

azurophil granule lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	25416956 25910212 30021884 32296183 33961781 35271311 37207277
glycogen phosphorylase activity	NAS	3346228
glycogen phosphorylase activity	IBA
pyridoxal phosphate binding	IBA
maltodextrin phosphorylase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

1,4-alpha-oligoglucan phosphorylase activity [inference]

binding [inference]

protein binding

small molecule binding [inference]

vitamin binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

heterocyclic compound binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

ion binding [inference]

anion binding [inference]

pyridoxal phosphate binding

organic cyclic compound binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Phosphorylase

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
1,4-alpha-oligoglucan phosphorylase activity
SHG alpha-glucan phosphorylase activity
glycogen catabolic process
glycogen phosphorylase activity
linear malto-oligosaccharide phosphorylase activity
pyridoxal phosphate binding
transferase activity

Displaying **all 3** entries
InterPro
Glycogen/starch/alpha-glucan phosphorylase
Glycosyl transferase, family 35
Phosphorylase pyridoxal-phosphate attachment site

Human Protein Atlas

ENSG00000100994

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00688

Name

glycogen phosphorylase [EC:2.4.1.1]

References

2877458

Rhea

phosphate

α-D-glucose 1-phosphate

Enzyme

2.4.1.1

PMID

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5834	Xenbase:XB-GENE-955302
Saccharomyces cerevisiae S288C	5836	SGD:S000006364
Saccharomyces cerevisiae S288C	5837	SGD:S000006364
Saccharomyces cerevisiae S288C	19309	SGD:S000006364
Rattus norvegicus	25739	Xenbase:XB-GENE-955302	RATNO28968
Xenopus tropicalis	33386	Xenbase:XB-GENE-955302
Saccharomyces cerevisiae S288C	64035	SGD:S000006364
Mus musculus	110078	Xenbase:XB-GENE-955302	MOUSE36009
Saccharomyces cerevisiae S288C	110095	SGD:S000006364
Danio rerio	403051		DANRE50843

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GlyCosmos Portal v4.2.1

Last updated: April 7, 2025