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glycogen phosphorylase B

Summary

Gene Symbol

PYGB

Aliases

glycogen phosphorylase, brain form

Organism

Homo sapiens (human)

External Links

NCBI Gene

5834

HGNC

9723

KEGG Gene ID

hsa:5834

PubChem

5834

Alliance of Genome Resources

HGNC:9723

Annotation

Keyword

3D-structure
Acetylation
Allosteric enzyme
Direct protein sequencing
Glycogen metabolism
Glycosyltransferase
Phosphoprotein
Pyridoxal phosphate
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P11216

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
glycogen catabolic process	IBA NAS	3346228

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process [inference]

glycogen catabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process [inference]

glycogen catabolic process

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process [inference]

glycogen catabolic process

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process [inference]

glycogen catabolic process

glucan catabolic process [inference]

glycogen catabolic process

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process [inference]

glycogen catabolic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular region	TAS
cytoplasm	IBA IDA	10638593
membrane	HDA	19946888
extracellular exosome	HDA	23533145
azurophil granule lumen	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

azurophil granule lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
linear malto-oligosaccharide phosphorylase activity	IEA
SHG alpha-glucan phosphorylase activity	IEA
pyridoxal phosphate binding	IBA
glycogen phosphorylase activity	IBA NAS	3346228
protein binding	IPI	25416956 25910212 32296183 37207277

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

1,4-alpha-oligoglucan phosphorylase activity [inference]

glycogen phosphorylase activity

binding [inference]

protein binding

small molecule binding [inference]

vitamin binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

heterocyclic compound binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

ion binding [inference]

anion binding [inference]

pyridoxal phosphate binding

organic cyclic compound binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000100994

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00688

Name

glycogen phosphorylase [EC:2.4.1.1]

References

2877458

Rhea

phosphate

α-D-glucose 1-phosphate

Enzyme

2.4.1.1

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 15 in total

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DO ID	Disease Name	Source
DOID:0080202	adenoid cystic carcinoma	DisGeNET
DOID:11847	coronary thrombosis	DisGeNET
DOID:1324	lung cancer	DisGeNET
DOID:1612	breast cancer	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET
DOID:3393	coronary artery disease	DisGeNET
DOID:3908	lung non-small cell carcinoma	DisGeNET
DOID:4766	embryoma	DisGeNET
DOID:4866	salivary gland adenoid cystic carcinoma	DisGeNET
DOID:5844	myocardial infarction	DisGeNET

Ortholog

Displaying entries **1 - 10** of 75 in total

1

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	178777	WB:WBGene00020696
Drosophila melanogaster	33386	FB:FBgn0004507
Callorhinchus milii	103179206		CALMI17281
Danio rerio	403051	ZFIN:ZDB-GENE-040928-2
Ictalurus punctatus	108270071		ICTPU35989
Electrophorus electricus	113582163		ELEEL28522
Salmo trutta	115193879		SALTR89720
Oryzias latipes	101170949		ORYLA04779
Xenopus laevis	100037229	Xenbase:XB-GENE-966442
Xenopus laevis	108713966	Xenbase:XB-GENE-17342994

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.0.0

Last updated: August 19, 2024