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junctional adhesion molecule 2

Summary

Gene Symbol

JAM2

Organism

Homo sapiens (human)

External Links

NCBI Gene

58494

PubChem

58494

Alliance of Genome Resources

HGNC:14686

Annotation

Keyword

Alternative splicing
Cell membrane
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Immunoglobulin domain
Reference proteome
Signal
Tight junction
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P57087	Junctional adhesion molecule 2 Vascular endothelial junction-associated molecule

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cell-cell adhesion	IMP NAS	10779521 24357068
leukocyte tethering or rolling	IDA	19740376
maintenance of blood-brain barrier	NAS	30280653
spermatid development	ISS
positive regulation of lymphocyte migration	IDA	12239159

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

cellular extravasation

cellular process [inference]

syncytium formation [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

cell adhesion [inference]

cell-cell adhesion

leukocyte cell-cell adhesion

leukocyte adhesion to vascular endothelial cell [inference]

leukocyte tethering or rolling

leukocyte aggregation [inference]

lymphocyte aggregation

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

spermatid development

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

spermatid development

cell motility [inference]

cell migration [inference]

hematopoietic stem cell migration [inference]

hematopoietic stem cell migration to bone marrow

leukocyte migration [inference]

cellular extravasation

cell-cell fusion [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

reproductive process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

spermatid development

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

spermatid development

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of blood-brain barrier

developmental process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

spermatid development

anatomical structure formation involved in morphogenesis [inference]

syncytium formation [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

anatomical structure development [inference]

cell development [inference]

germ cell development [inference]

spermatid development

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

spermatid development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of blood-brain barrier

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

regulation of lymphocyte migration [inference]

positive regulation of lymphocyte migration

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

regulation of lymphocyte migration [inference]

positive regulation of lymphocyte migration

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of myelination

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of myelination

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination [inference]

negative regulation of myelination

regulation of cellular process [inference]

regulation of myelination [inference]

negative regulation of myelination

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

negative regulation of cellular process [inference]

negative regulation of myelination

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

regulation of lymphocyte migration [inference]

positive regulation of lymphocyte migration

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

negative regulation of nervous system process [inference]

negative regulation of myelination

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of myelination

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination [inference]

negative regulation of myelination

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
bicellular tight junction	IEA
protein complex involved in cell adhesion	IBA IDA	11590146

GO Hierarchy

cellular component

protein-containing complex [inference]

protein complex involved in cell adhesion

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

cell-cell contact zone

tight junction

bicellular tight junction

somatodendritic compartment

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11590146 11823489 21982860
integrin binding	IDA	12070135

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Junctional adhesion molecule A

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060230	basal ganglia calcification	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 71 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	67374		MGI:1933820	MOUSE18708
Caenorhabditis elegans	188896		WB:WBGene00020800
Pan troglodytes	458486	9598_0:005311		PANTR25455
Bos taurus	538846			BOVIN14271
Rattus norvegicus	619374		RGD:1561692	RATNO04259
Xenopus tropicalis	779665		Xenbase:XB-GENE-493973
Danio rerio	100005261		ZFIN:ZDB-GENE-031204-3
Danio rerio	100005301		ZFIN:ZDB-GENE-080229-3
Monodelphis domestica	100012735			MONDO22844
Monodelphis domestica	100022671			MONDO22844