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proline dehydrogenase 2

Summary

Gene Symbol

PRODH2

Organism

Homo sapiens (human)

External Links

NCBI Gene

58510

PubChem

58510

Alliance of Genome Resources

HGNC:17325

Annotation

Keyword

Acetylation
FAD
Oxidoreductase
Proline metabolism
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UF12	Kidney and liver proline oxidase 1 Probable proline dehydrogenase 2 Probable proline oxidase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
proline catabolic process to glutamate	IBA
proline catabolic process	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

amide catabolic process [inference]

proline catabolic process to glutamate

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

proline metabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

catabolic process [inference]

amide catabolic process [inference]

proline catabolic process to glutamate

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

proline metabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

proline metabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

proline metabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

proline metabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

proline metabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

proline metabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrial inner membrane	TAS
mitochondrion	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 3** entries
GO Term	Evidence Code	PMID
FAD binding	IBA
proline dehydrogenase activity	IBA TAS
oxidoreductase activity, acting on the CH-NH group of donors	IDA	25697095

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-NH group of donors

oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor [inference]

proline dehydrogenase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

PROLINE DEHYDROGENASE

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
FAD binding
oxidoreductase activity
proline catabolic process
proline dehydrogenase activity
proline metabolic process

Displaying **all 3** entries
InterPro
FAD-linked oxidoreductase-like
Proline dehydrogenase domain
Proline oxidase family

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060413	chromosome 22q11.2 deletion syndrome, distal	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 58 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	56189		MGI:1929093	MOUSE55077
Caenorhabditis elegans	178350		WB:WBGene00007197
Rattus norvegicus	361538		RGD:1306761	RATNO19775
Xenopus laevis	398760		Xenbase:XB-GENE-5784821
Danio rerio	436664		ZFIN:ZDB-GENE-040718-87	DANRE04120
Pan troglodytes	469076	9598_0:004f02
Canis lupus familiaris	484572			CANLF01181
Bos taurus	508542			BOVIN10917
Macaca mulatta	718914			MACMU18065
Saccharomyces cerevisiae S288C	850833		SGD:S000004132

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024