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epidermal growth factor-containing fibulin-like extracellular matrix protein 2

Summary

Gene Symbol

Efemp2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

58859

PubChem

58859

Alliance of Genome Resources

MGI:1891209

Annotation

Keyword

Basement membrane
Calcium
Direct protein sequencing
Disulfide bond
EGF-like domain
Extracellular matrix
Glycoprotein
Proteomics identification
Pyrrolidone carboxylic acid
Reference proteome
Repeat
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q542X5
G5E8D6
Q9WVJ9	Fibulin-4 Mutant p53-binding protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
aorta development	IMP	20019329
elastic fiber assembly	ISS
elastic fiber assembly	ISO
elastic fiber assembly	IMP	16478991 19855011 20019329 26178373 26711913 28508064
aorta smooth muscle tissue morphogenesis	IMP	26178373 26711913

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

vascular associated smooth muscle cell development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

extracellular matrix assembly [inference]

elastic fiber assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly [inference]

elastic fiber assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly [inference]

elastic fiber assembly

supramolecular fiber organization [inference]

elastic fiber assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

tissue morphogenesis [inference]

muscle tissue morphogenesis [inference]

aorta smooth muscle tissue morphogenesis

anatomical structure development [inference]

blood vessel development [inference]

artery development

aorta development

cell development [inference]

muscle cell development [inference]

vascular associated smooth muscle cell development

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

vascular associated smooth muscle cell development

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion [inference]

positive regulation of smooth muscle cell-matrix adhesion

positive regulation of cellular component organization [inference]

positive regulation of supramolecular fiber organization [inference]

positive regulation of collagen fibril organization

positive regulation of extracellular matrix organization [inference]

positive regulation of collagen fibril organization

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of smooth muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of vascular associated smooth muscle cell differentiation [inference]

regulation of aortic smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

positive regulation of cell-matrix adhesion [inference]

positive regulation of smooth muscle cell-matrix adhesion

regulation of smooth muscle cell-matrix adhesion [inference]

positive regulation of smooth muscle cell-matrix adhesion

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion [inference]

positive regulation of smooth muscle cell-matrix adhesion

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion [inference]

positive regulation of smooth muscle cell-matrix adhesion

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of vascular associated smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of smooth muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of vascular associated smooth muscle cell differentiation [inference]

regulation of aortic smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion [inference]

positive regulation of smooth muscle cell-matrix adhesion

positive regulation of cellular component organization [inference]

positive regulation of supramolecular fiber organization [inference]

positive regulation of collagen fibril organization

positive regulation of extracellular matrix organization [inference]

positive regulation of collagen fibril organization

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of supramolecular fiber organization [inference]

positive regulation of collagen fibril organization

positive regulation of extracellular matrix organization [inference]

positive regulation of collagen fibril organization

regulation of supramolecular fiber organization [inference]

positive regulation of supramolecular fiber organization [inference]

positive regulation of collagen fibril organization

regulation of collagen fibril organization

positive regulation of collagen fibril organization

regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix organization [inference]

positive regulation of collagen fibril organization

regulation of collagen fibril organization

positive regulation of collagen fibril organization

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
microfibril	IDA	17324935
basement membrane	IDA	17324935
extracellular space	HDA	24006456
extracellular matrix	ISO
extracellular matrix	TAS	10982184

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

basement membrane

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
calcium ion binding	IEA
protein binding	IPI	16478991 17324935 19855011 25713297 26220971 28717224
heparin binding	ISS
heparin binding	ISO
extracellular matrix constituent conferring elasticity	RCA	22159717

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent [inference]

extracellular matrix constituent conferring elasticity

structural molecule activity conferring elasticity [inference]

extracellular matrix constituent conferring elasticity

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

EGF-containing fibulin-like extracellular matrix protein 2

Functional Category

F: Nucleotide transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 5** entries
Gene Ontology
calcium ion binding
elastic fiber assembly
heparin binding
positive regulation of smooth muscle cell-matrix adhesion
protein homodimerization activity

Displaying **all 8** entries
InterPro
Complement Clr-like EGF domain
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-like, conserved site
EGF-type aspartate/asparagine hydroxylation site
Growth factor receptor cysteine-rich domain superfamily
NOTCH1 EGF-like calcium-binding domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:3144	cutis laxa	Alliance of Genome Resources
DOID:3627	aortic aneurysm	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 67 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	30008	Xenbase:XB-GENE-1013529	HUMAN07260
Xenopus tropicalis	58859	Xenbase:XB-GENE-1013529
Rattus norvegicus	293677		RATNO16844
Pan troglodytes	451335		PANTR03436
Danio rerio	494044		DANRE07711
Bos taurus	535222		BOVIN23481
Macaca mulatta	721877		MACMU10679
Equus caballus	100057642		HORSE05399
Ornithorhynchus anatinus	100085019		ORNAN17894
Pongo abelii	100452252		PONAB03469