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RAN binding protein 2

Summary

Gene Symbol

RANBP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

5903

PubChem

5903

Alliance of Genome Resources

HGNC:9848

Annotation

Keyword

3D-structure
Acetylation
Chromosomal rearrangement
Disulfide bond
Isopeptide bond
Membrane
Methylation
Nuclear pore complex
Phosphoprotein
RNA-binding
Reference proteome
Repeat
TPR repeat
Transferase
Ubl conjugation
Ubl conjugation pathway
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
P49792	358 kDa nucleoporin Nuclear pore complex protein Nup358 Nucleoporin Nup358 Ran-binding protein 2 p270

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
protein folding	IEA
NLS-bearing protein import into nucleus	IBA IMP	7603572
mRNA transport	IEA
protein sumoylation	IDA IEA TAS	22155184 22194619
nuclear export	EXP	27160050

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

peptidyl-proline modification [inference]

protein peptidyl-prolyl isomerization

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

peptidyl-proline modification [inference]

protein peptidyl-prolyl isomerization

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

peptidyl-proline modification [inference]

protein peptidyl-prolyl isomerization

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

peptidyl-proline modification [inference]

protein peptidyl-prolyl isomerization

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein sumoylation

peptidyl-proline modification [inference]

protein peptidyl-prolyl isomerization

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

cellular process [inference]

protein folding

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export

import into nucleus [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

microtubule organizing center localization [inference]

centrosome localization

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export

import into nucleus [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

mRNA transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

mRNA transport

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

establishment of RNA localization [inference]

RNA transport [inference]

mRNA transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export

import into nucleus [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export

import into nucleus [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

microtubule organizing center localization [inference]

centrosome localization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis

regulation of small molecule metabolic process [inference]

regulation of glucose metabolic process [inference]

regulation of gluconeogenesis

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process [inference]

regulation of gluconeogenesis

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
nuclear inclusion body	IDA	11839768
SUMO ligase complex	IPI	22194619
nuclear membrane	IDA	11839768
membrane	HDA	19946888
cytoplasmic periphery of the nuclear pore complex	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

SUMO ligase complex

cellular anatomical entity [inference]

intracellular anatomical structure [inference]

inclusion body [inference]

nuclear inclusion body

membrane

annulate lamellae

organelle membrane [inference]

nuclear membrane

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

perinuclear region of cytoplasm [inference]

cytoplasmic periphery of the nuclear pore complex

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
GTPase activator activity	IBA
protein binding	IPI	10078529 14729961 16204249 16314522 16332688 20386726 20936779 21988832 22155184 22194619 23414517 24855949 26272610 26496610 28514442 33961781 34400285 35271311 37219487
protein-containing complex binding	IEA
small GTPase binding	IPI	7603572
SUMO transferase activity	EXP	11792325 15378033 15608651 22464730

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

SUMO transferase activity

SUMO ligase activity

ubiquitin-like protein ligase activity [inference]

SUMO ligase activity

isomerase activity [inference]

cis-trans isomerase activity [inference]

peptidyl-prolyl cis-trans isomerase activity

catalytic activity, acting on a protein [inference]

peptidyl-prolyl cis-trans isomerase activity

ubiquitin-like protein transferase activity [inference]

SUMO transferase activity

SUMO ligase activity

ubiquitin-like protein ligase activity [inference]

SUMO ligase activity

binding [inference]

protein binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

RanBP2

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
NLS-bearing protein import into nucleus

Displaying **all 5** entries
InterPro
PH-like domain superfamily
Ran binding domain
Ran binding protein RanBP1-like
Tetratricopeptide repeat
Tetratricopeptide-like helical domain superfamily

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050905	inflammatory myofibroblastic tumor	Alliance of Genome Resources
DOID:936	brain disease	Alliance of Genome Resources
DOID:9538	multiple myeloma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 91 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	19386		MGI:894323	MOUSE01283
Drosophila melanogaster	43041		FB:FBgn0039302
Caenorhabditis elegans	175443		WB:WBGene00003795
Rattus norvegicus	294429		RGD:1560047	RATNO22079
Canis lupus familiaris	474539			CANLF01713
Macaca mulatta	694823			MACMU07758
Pan troglodytes	736102	9598_0:0009ac
Monodelphis domestica	100020173			MONDO31373
Equus caballus	100060826			HORSE10260
Ornithorhynchus anatinus	100090614			ORNAN15425

GlyTouCan

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements