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retinoic acid receptor responder 2

Summary

Gene Symbol

RARRES2

Organism

Homo sapiens (human)

External Links

NCBI Gene

5919

PubChem

5919

Alliance of Genome Resources

HGNC:9868

Annotation

Keyword

3D-structure
Chemotaxis
Differentiation
Direct protein sequencing
Disulfide bond
Inflammatory response
Receptor
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A090N7U9	Chemerin
Q99969	Chemerin RAR-responsive protein TIG2 Tazarotene-induced gene 2 protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
insulin receptor signaling pathway	IDA	18242188
inflammatory response	IEA
embryonic digestive tract development	IMP	19443732
antifungal innate immune response	IMP	23527010
chemotaxis	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response [inference]

antifungal humoral response

innate immune response

antifungal innate immune response

metabolic process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

insulin receptor signaling pathway

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

cellular developmental process [inference]

cell differentiation

developmental process [inference]

anatomical structure development [inference]

tube development [inference]

digestive tract development [inference]

embryonic digestive tract development

animal organ development [inference]

embryonic organ development [inference]

embryonic digestive tract development

cellular developmental process [inference]

cell differentiation

locomotion [inference]

taxis [inference]

chemotaxis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

response to fungus [inference]

defense response to fungus [inference]

defense response to other organism [inference]

antimicrobial humoral response [inference]

antifungal humoral response

defense response to bacterium [inference]

innate immune response

antifungal innate immune response

defense response to fungus [inference]

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

antimicrobial humoral response [inference]

antifungal humoral response

defense response to bacterium [inference]

innate immune response

antifungal innate immune response

defense response to fungus [inference]

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response [inference]

antifungal humoral response

innate immune response

antifungal innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

response to fungus [inference]

defense response to fungus [inference]

defense response to other organism [inference]

antimicrobial humoral response [inference]

antifungal humoral response

defense response to bacterium [inference]

innate immune response

antifungal innate immune response

defense response to fungus [inference]

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

response to fungus [inference]

defense response to fungus [inference]

defense response to other organism [inference]

antimicrobial humoral response [inference]

antifungal humoral response

defense response to bacterium [inference]

innate immune response

antifungal innate immune response

defense response to fungus [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of catabolic process [inference]

regulation of lipid catabolic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of lipid catabolic process

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of chemotaxis

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of locomotion [inference]

positive regulation of chemotaxis

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of chemotaxis

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

insulin receptor signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of macrophage chemotaxis

positive regulation of macrophage migration [inference]

positive regulation of macrophage chemotaxis

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular matrix	IBA
extracellular space	IBA IDA	23527010
extracellular region	ISS TAS
collagen-containing extracellular matrix	IDA	19443732
platelet dense granule lumen	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet dense granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet dense granule lumen

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	14530373 33961781
signaling receptor binding	IBA IPI	14530373

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

retinoic acid receptor responder 2

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
cell differentiation
chemotaxis
inflammatory response
positive regulation of chemotaxis
regulation of lipid catabolic process
signaling receptor binding

Displaying **all 2** entries
InterPro
Cystatin superfamily
Retinoic acid receptor responder protein 2

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0080208	metabolic dysfunction-associated steatotic liver disease	Alliance of Genome Resources
DOID:10825	essential hypertension	Alliance of Genome Resources
DOID:11612	polycystic ovary syndrome	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 54 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	71660		MGI:1918910	MOUSE48300
Rattus norvegicus	297073		RGD:1309874	RATNO31571
Canis lupus familiaris	475532			CANLF04566
Bos taurus	508990			BOVIN28709
Macaca mulatta	704993			MACMU33076
Pan troglodytes	735446	9598_0:00234d		PANTR41744
Monodelphis domestica	100016838			MONDO33239
Sus scrofa	100141314			PIGXX13036
Pongo abelii	100174710	9601_0:00215b		PONAB33683
Oryctolagus cuniculus	100346066			RABIT16415

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements