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angiotensin converting enzyme 2

Summary

Gene Symbol

ACE2

Organism

Homo sapiens (human)

External Links

NCBI Gene

59272

PubChem

59272

Alliance of Genome Resources

HGNC:13557

Annotation

Keyword

3D-structure
Alternative splicing
Carboxypeptidase
Cell membrane
Cell projection
Chloride
Cytoplasm
Direct protein sequencing
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Isopeptide bond
Metal-binding
Metalloprotease
Phosphoprotein
Reference proteome
Secreted
Signal
Transmembrane helix
Ubl conjugation
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9BYF1	Angiotensin-converting enzyme homolog Angiotensin-converting enzyme-related carboxypeptidase Metalloprotease MPROT15

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **26 - 30** of 30 in total

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GO Term	Evidence Code	PMID
positive regulation of gap junction assembly	IMP	12967627
regulation of cardiac conduction	IMP	12967627
positive regulation of L-proline import across plasma membrane	IGI	25534429
negative regulation of signaling receptor activity
positive regulation of reactive oxygen species metabolic process	IC	15380922

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

hormone metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

membrane fusion

viral process [inference]

viral life cycle

transport of virus [inference]

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell

reproductive process [inference]

multicellular organismal reproductive process [inference]

maternal process involved in female pregnancy

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance

regulation of vasoconstriction

endocrine process [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by renin-angiotensin

behavior [inference]

feeding behavior [inference]

drinking behavior [inference]

angiotensin-mediated drinking behavior

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

adhesion of symbiont to host [inference]

adhesion of symbiont to host cell [inference]

virion attachment to host cell [inference]

receptor-mediated virion attachment to host cell

entry receptor-mediated virion attachment to host cell

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

amino acid transport [inference]

aromatic amino acid transport [inference]

tryptophan transport

organic acid transport [inference]

carboxylic acid transport [inference]

amino acid transport [inference]

aromatic amino acid transport [inference]

tryptophan transport

nitrogen compound transport [inference]

amino acid transport [inference]

aromatic amino acid transport [inference]

tryptophan transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production

regulation of reactive oxygen species metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of signaling receptor activity [inference]

negative regulation of signaling receptor activity

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of localization [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amino acid transport [inference]

positive regulation of amino acid transport

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of proline transport [inference]

regulation of L-proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of proline import across plasma membrane [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of L-proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity

positive regulation of transmembrane transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of proline import across plasma membrane [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of L-proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of transmembrane transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of amine transport [inference]

positive regulation of amino acid transport

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amine transport [inference]

positive regulation of amine transport [inference]

positive regulation of amino acid transport

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amino acid transport [inference]

positive regulation of amino acid transport

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of proline transport [inference]

regulation of L-proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of proline import across plasma membrane [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of L-proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

positive regulation of transmembrane transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of transmembrane transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of amine transport [inference]

positive regulation of amino acid transport

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of multicellular organismal process [inference]

positive regulation of muscle contraction [inference]

positive regulation of striated muscle contraction [inference]

positive regulation of cardiac muscle contraction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of cardiac muscle contraction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of signaling receptor activity [inference]

negative regulation of signaling receptor activity

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of response to external stimulus [inference]

regulation of inflammatory response

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of signaling receptor activity [inference]

negative regulation of signaling receptor activity

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production

regulation of reactive oxygen species metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity

positive regulation of transmembrane transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of proline import across plasma membrane [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of L-proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

regulation of cell population proliferation

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

negative regulation of smooth muscle cell proliferation

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

regulation of cell junction assembly [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

regulation of gap junction assembly [inference]

positive regulation of gap junction assembly

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

positive regulation of transmembrane transport [inference]

positive regulation of proline import across plasma membrane [inference]

positive regulation of L-proline import across plasma membrane

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

regulation of cell junction assembly [inference]

positive regulation of cell junction assembly [inference]

positive regulation of gap junction assembly

regulation of gap junction assembly [inference]

positive regulation of gap junction assembly

regulation of multicellular organismal process [inference]

regulation of cytokine production

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

positive regulation of striated muscle contraction [inference]

positive regulation of cardiac muscle contraction

regulation of cardiac muscle contraction [inference]

positive regulation of cardiac muscle contraction

positive regulation of muscle contraction [inference]

positive regulation of striated muscle contraction [inference]

positive regulation of cardiac muscle contraction

regulation of blood circulation [inference]

regulation of heart contraction [inference]

positive regulation of heart contraction [inference]

positive regulation of cardiac muscle contraction

regulation of cardiac muscle contraction [inference]

positive regulation of cardiac muscle contraction

regulation of cardiac conduction

regulation of vasoconstriction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of cardiac muscle contraction

positive regulation of multicellular organismal process [inference]

positive regulation of muscle contraction [inference]

positive regulation of striated muscle contraction [inference]

positive regulation of cardiac muscle contraction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of cardiac muscle contraction

regulation of biological quality [inference]

regulation of blood pressure [inference]

regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure mediated by a chemical signal [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by renin-angiotensin

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance

regulation of vasoconstriction

regulation of molecular function [inference]

regulation of signaling receptor activity [inference]

negative regulation of signaling receptor activity

regulation of transporter activity [inference]

regulation of transmembrane transporter activity

negative regulation of molecular function [inference]

negative regulation of signaling receptor activity

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GO Term	Evidence Code	PMID
extracellular region	IDA	10969042 33713620
extracellular space	IDA	18258853
extracellular space	IBA
endoplasmic reticulum lumen	TAS
plasma membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endocytic vesicle membrane

bounding membrane of organelle [inference]

endocytic vesicle membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

membrane microdomain [inference]

membrane raft

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
virus receptor activity	IDA	16051304 18343844 33000221 33077916 33082294 33163980 33713620 36228039 36735681 36757924
virus receptor activity	IMP	24227843
endopeptidase activity	IDA	15283675
carboxypeptidase activity	IDA	10924499 10969042 15283675 15380922 18258853 33077916
metallocarboxypeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

metallopeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

peptidyl-dipeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

metallopeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

peptidyl-dipeptidase activity

binding [inference]

protein binding

identical protein binding

exogenous protein binding [inference]

virus receptor activity

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

angiotensin-converting enzyme

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
carboxypeptidase activity
hydrolase activity
metal ion binding
metallopeptidase activity
peptidyl-dipeptidase activity
proteolysis

Displaying 1 entry
InterPro
Peptidase M2, peptidyl-dipeptidase A

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:1273	respiratory syncytial virus infectious disease	Alliance of Genome Resources
DOID:14069	cerebral malaria	Alliance of Genome Resources
DOID:2945	severe acute respiratory syndrome	Alliance of Genome Resources
DOID:4492	avian influenza	Alliance of Genome Resources
DOID:6432	pulmonary hypertension	Alliance of Genome Resources
DOID:8947	diabetic retinopathy	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 90 in total

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Species	Gene ID	Orthologous MAtrix
Loxodonta africana	100663153	LOXAF08571
Oreochromis niloticus	100699386	ORENI33847
Cricetulus griseus	100772552	CRIGR11067
Otolemur garnettii	100951881	OTOGA10257
Pan paniscus	100970340	PANPA40920
Papio anubis	101008749	PAPAN42906
Saimiri boliviensis boliviensis	101045190	SAIBB01152
Ovis aries	101103622	SHEEP19530
Gorilla gorilla gorilla	101142534	GORGO43851
Tursiops truncatus	101326506	TURTR02716

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

International Collaboration

Acknowledgements