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MIRAGE
erb-b2 receptor tyrosine kinase 4
Summary
- Gene Symbol
-
- Erbb4
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- ATP-binding
- Activator
- Alternative splicing
- Apoptosis
- Cell membrane
- Developmental protein
- Disulfide bond
- Glycoprotein
- Lactation
- Mitochondrion
- Nucleus
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- Signal
- Transcription regulation
- Transmembrane helix
- Tyrosine-protein kinase
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| Q62956 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| mammary gland development | ||
| mitochondrial fragmentation involved in apoptotic process | ||
| cellular response to L-glutamate | ||
| cell surface receptor signaling pathway | ||
| protein phosphorylation |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
developmental process [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling
regulation of growth [inference]
positive regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication
regulation of cellular metabolic process [inference]
regulation of cell population proliferation
positive regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleus | ||
| basal plasma membrane | ||
| postsynaptic membrane | ||
| glutamatergic synapse | ||
| dendrite |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| transcription cis-regulatory region binding | ||
| ATP binding | ||
| epidermal growth factor receptor activity | ||
| epidermal growth factor receptor binding | ||
| protein tyrosine kinase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- receptor tyrosine-protein kinase erbB-4
- Functional Category
-
- C: Energy production and conversion
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| ERBB signaling pathway |
| kinase activity |
| nervous system development |
| neurogenesis |
| nucleotide binding |
| phosphorylation |
| positive regulation of cell population proliferation |
| regulation of cell communication |
| regulation of cell population proliferation |
| InterPro |
|---|
| Protein kinase domain |
| Protein kinase-like domain superfamily |
| Serine-threonine/tyrosine-protein kinase, catalytic domain |
Alliance of Genome Resources
- Expression
| Location | References |
|---|---|
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050700 | cardiomyopathy | |
| DOID:0050865 | tongue squamous cell carcinoma | |
| DOID:0050866 | oral squamous cell carcinoma | |
| DOID:0060074 | ductal carcinoma in situ | |
| DOID:0060210 | amyotrophic lateral sclerosis type 19 | |
| DOID:10155 | intestinal cancer | |
| DOID:10283 | prostate cancer | |
| DOID:10376 | amblyopia | |
| DOID:11054 | urinary bladder cancer | |
| DOID:11832 | visual epilepsy |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 2066 | HGNC:3432 | HUMAN66728 | ||
| 13869 | 10090_1:0003ba | MGI:104771 | MOUSE30055 | |
| 37455 | FB:FBgn0003731 | |||
| 174462 | WB:WBGene00002299 | |||
| 459919 | PANTR29684 | |||
| 488508 | CANLF14189 | |||
| 522419 | BOVIN24689 | |||
| 693341 | MACMU05555 | |||
| 778955 | CIOIN15841 | |||
| 100007677 | ZFIN:ZDB-GENE-030918-4 |
