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solute carrier family 5 member 7

Summary

Gene Symbol

SLC5A7

Organism

Homo sapiens (human)

External Links

NCBI Gene

60482

PubChem

60482

Alliance of Genome Resources

HGNC:14025

Annotation

Keyword

3D-structure
Cell membrane
Cell projection
Congenital myasthenic syndrome
Cytoplasmic vesicle
Disease variant
Endosome
Glycoprotein
Ion transport
Neurodegeneration
Neuropathy
Neurotransmitter biosynthesis
Phosphoprotein
Reference proteome
Sodium
Sodium transport
Symport
Synapse
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q9GZV3	Hemicholinium-3-sensitive choline transporter Solute carrier family 5 member 7
Q2T9H3
B4DUU7
B2RCU2

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
in utero embryonic development	IEA
sodium ion transport	IEA
neurotransmitter transport	TAS
synaptic transmission, cholinergic	IBA
neuromuscular synaptic transmission	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

acetylcholine metabolic process [inference]

acetylcholine biosynthetic process

organonitrogen compound biosynthetic process [inference]

acetylcholine biosynthetic process

biosynthetic process [inference]

organic substance biosynthetic process [inference]

acetate ester biosynthetic process [inference]

acetylcholine biosynthetic process

organonitrogen compound biosynthetic process [inference]

acetylcholine biosynthetic process

organic substance metabolic process [inference]

acetate ester metabolic process [inference]

acetylcholine metabolic process [inference]

acetylcholine biosynthetic process

acetate ester biosynthetic process [inference]

acetylcholine biosynthetic process

organonitrogen compound metabolic process [inference]

acetylcholine metabolic process [inference]

acetylcholine biosynthetic process

organonitrogen compound biosynthetic process [inference]

acetylcholine biosynthetic process

organic substance biosynthetic process [inference]

acetate ester biosynthetic process [inference]

acetylcholine biosynthetic process

organonitrogen compound biosynthetic process [inference]

acetylcholine biosynthetic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

transmembrane transport

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

organic substance transport [inference]

organic cation transport [inference]

choline transport

quaternary ammonium group transport [inference]

choline transport

nitrogen compound transport [inference]

quaternary ammonium group transport [inference]

choline transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	12237312
plasma membrane	IBA
membrane	IDA	11027560
axon	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

early endosome membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse

neuromuscular junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

perikaryon

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
choline:sodium symporter activity	IDA	11068039 17005849
choline:sodium symporter activity	IMP	12237312
choline:sodium symporter activity	IBA
choline transmembrane transporter activity	TAS
choline transmembrane transporter activity	IDA	11027560 11068039 12969261 17005849 23141292

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

choline:sodium symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

choline:sodium symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

choline:sodium symporter activity

organic cation transmembrane transporter activity [inference]

quaternary ammonium group transmembrane transporter activity [inference]

choline transmembrane transporter activity

choline:sodium symporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

choline:sodium symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

choline:sodium symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

choline:sodium symporter activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

choline:sodium symporter activity

choline transmembrane transporter activity

choline:sodium symporter activity

binding [inference]

ion binding [inference]

cation binding [inference]

choline binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

High affinity choline transporter 1

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
acetylcholine biosynthetic process
choline transport
choline
monoatomic ion transport
symporter activity

Displaying **all 2** entries
InterPro
Sodium/glucose symporter superfamily
Sodium/solute symporter

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0110661	congenital myasthenic syndrome 20	Alliance of Genome Resources
DOID:0111199	autosomal dominant distal hereditary motor neuronopathy 7	Alliance of Genome Resources
DOID:1596	depressive disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **132** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	42245	Xenbase:XB-GENE-961535
Xenopus tropicalis	60482	Xenbase:XB-GENE-961535
Mus musculus	63993	Xenbase:XB-GENE-961535	MOUSE20013
Rattus norvegicus	85426	Xenbase:XB-GENE-961535	RATNO43920
Xenopus tropicalis	178274	Xenbase:XB-GENE-961535
Pan troglodytes	470492		PANTR28396
Canis lupus familiaris	481311		CANLF01720
Bos taurus	512311		BOVIN02466
Macaca mulatta	714093		MACMU07615
Danio rerio	100005589		DANRE17756

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements