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interleukin 1 receptor antagonist

Summary

Gene Symbol

Il1rn

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

60582

PubChem

60582

Alliance of Genome Resources

RGD:621159

Annotation

Keyword

Disulfide bond
Glycoprotein
Receptor
Reference proteome
Secreted
Signal

Proteins

Displaying **all 5** entries
UniProt	Protein Name
A6JSY3
A6JSY5
A0A0H2UHE2
A6JSY4
P25086	IL1 inhibitor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 35 in total

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GO Term	Evidence Code	PMID
fever generation	IMP	16455768
inflammatory response to antigenic stimulus
chronic inflammatory response to antigenic stimulus	IEP	15050649
lipid metabolic process	ISO
acute-phase response	ISO

GO Hierarchy

biological process

immune system process [inference]

immune response

inflammatory response to antigenic stimulus

chronic inflammatory response to antigenic stimulus

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process

primary metabolic process [inference]

lipid metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process

lipid metabolic process

cellular process [inference]

signal transduction

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory

behavior [inference]

learning or memory [inference]

memory

multi-multicellular organism process [inference]

female pregnancy

multicellular organismal-level homeostasis [inference]

temperature homeostasis [inference]

heat generation [inference]

fever generation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

temperature homeostasis [inference]

heat generation [inference]

fever generation

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

inflammatory response to antigenic stimulus

chronic inflammatory response to antigenic stimulus

acute inflammatory response [inference]

acute-phase response

fever generation

chronic inflammatory response [inference]

chronic inflammatory response to antigenic stimulus

response to starvation

immune response

inflammatory response to antigenic stimulus

chronic inflammatory response to antigenic stimulus

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to starvation

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to activity

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to monoamine [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to norepinephrine [inference]

cellular response to norepinephrine stimulus

response to organic cyclic compound

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

cellular response to organic cyclic compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to norepinephrine [inference]

cellular response to norepinephrine stimulus

response to lipid [inference]

response to lipopolysaccharide

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to cytokine [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to monoamine [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to norepinephrine [inference]

cellular response to norepinephrine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to oxygen-containing compound [inference]

response to lipopolysaccharide

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to norepinephrine [inference]

cellular response to norepinephrine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

secretion [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

organic substance transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

nitrogen compound transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

amide transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of JUN kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of JUN kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of JUN kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of JUN kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of JUN kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

negative regulation of signal transduction

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

negative regulation of signaling [inference]

negative regulation of signal transduction

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

regulation of amino acid transport [inference]

regulation of glutamate secretion [inference]

negative regulation of glutamate secretion

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

regulation of secretion by cell [inference]

regulation of glutamate secretion [inference]

negative regulation of glutamate secretion

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

negative regulation of transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

regulation of amine transport [inference]

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

regulation of amino acid transport [inference]

regulation of glutamate secretion [inference]

negative regulation of glutamate secretion

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of heterotypic cell-cell adhesion

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of response to stimulus [inference]

negative regulation of signal transduction

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

negative regulation of signal transduction

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

negative regulation of response to stimulus [inference]

negative regulation of signal transduction

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

negative regulation of signal transduction

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of heterotypic cell-cell adhesion

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of heterotypic cell-cell adhesion

regulation of heterotypic cell-cell adhesion [inference]

negative regulation of heterotypic cell-cell adhesion

regulation of cell-cell adhesion involved in gastrulation [inference]

negative regulation of heterotypic cell-cell adhesion

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of JUN kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of JUN kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of heterotypic cell-cell adhesion

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of secretion by cell [inference]

regulation of glutamate secretion [inference]

negative regulation of glutamate secretion

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

regulation of membrane potential [inference]

negative regulation of membrane potential

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

regulation of JUN kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity [inference]

positive regulation of JUN kinase activity

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
extracellular region	ISO
extracellular space	ISO
extracellular space	IDA	17138728
extracellular space	IBA
extracellular space	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

cytosol

organelle [inference]

membrane-bounded organelle [inference]

vesicle

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
cytokine activity	IEA
interleukin-1 receptor binding	ISO
interleukin-1 receptor binding	IDA	1834644
interleukin-1 receptor binding	IEA
interleukin-1, type I receptor binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

interleukin-1 receptor binding

interleukin-1 receptor antagonist activity

receptor ligand activity [inference]

cytokine activity

receptor antagonist activity [inference]

interleukin-1 receptor antagonist activity

growth factor receptor binding [inference]

interleukin-1 receptor binding

growth factor binding [inference]

interleukin-1 binding [inference]

interleukin-1 receptor antagonist activity

cytokine binding [inference]

interleukin-1 binding [inference]

interleukin-1 receptor antagonist activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

signaling receptor inhibitor activity [inference]

receptor antagonist activity [inference]

interleukin-1 receptor antagonist activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function inhibitor activity [inference]

signaling receptor inhibitor activity [inference]

receptor antagonist activity [inference]

interleukin-1 receptor antagonist activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

interleukin-1 receptor antagonist protein

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
cytokine activity
immune response
inflammatory response to antigenic stimulus
inflammatory response
interleukin-1 receptor antagonist activity
interleukin-1 receptor binding
negative regulation of interleukin-1-mediated signaling pathway

Displaying **all 3** entries
InterPro
Cytokine IL1/FGF
Interleukin-1 family
Interleukin-1 receptor antagonist/Interleukin-36

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:17138728

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:10325	silicosis	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:11394	adult respiratory distress syndrome	Alliance of Genome Resources
DOID:224	transient cerebral ischemia	Alliance of Genome Resources
DOID:4780	anti-basement membrane glomerulonephritis	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 46** of 46 in total

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Species	Gene ID	Orthologous MAtrix
Vulpes vulpes	112916649	VULVU09237
Pseudonaja textilis	113445758	PSETE18887
Bos indicus x Bos taurus	113901273	BOBOX20137
Rhinolophus ferrumequinum	117019343	RHIFE33481
Panthera leo	122216315	PANLE01205
Ursus americanus	123799738	URSAM10645

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements