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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
ryanodine receptor 2
Summary
- Gene Symbol
-
- RYR2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Calcium channel
- Calmodulin-binding
- Cardiomyopathy
- Coiled coil
- Developmental protein
- Disease variant
- Ligand-gated ion channel
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- Sarcoplasmic reticulum
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| Q92736 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| striated muscle contraction | ||
| positive regulation of sequestering of calcium ion | ||
| establishment of localization in cell | ||
| regulation of AV node cell action potential | ||
| cellular response to epinephrine stimulus |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| sarcoplasmic reticulum membrane | ||
| membrane | ||
| sarcolemma | ||
| protein-containing complex | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| calmodulin binding | ||
| suramin binding | ||
| enzyme binding | ||
| ryanodine-sensitive calcium-release channel activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- E3 ubiquitin-protein ligase
- Functional Category
-
- E: Amino acid transport and metabolism
- J: Translation, ribosomal structure and biogenesis
- T: Signal transduction mechanisms
| InterPro |
|---|
| B30.2/SPRY domain superfamily |
| B30.2/SPRY domain |
| Concanavalin A-like lectin/glucanase domain superfamily |
| SPRY domain |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050431 | arrhythmogenic right ventricular cardiomyopathy | |
| DOID:0060675 | catecholaminergic polymorphic ventricular tachycardia 1 | |
| DOID:10591 | pre-eclampsia | |
| DOID:114 | heart disease | |
| DOID:11714 | gestational diabetes | |
| DOID:1574 | alcohol use disorder | |
| DOID:3529 | congenital myopathy 1A | |
| DOID:6000 | congestive heart failure | |
| DOID:6432 | pulmonary hypertension | |
| DOID:8545 | malignant hyperthermia |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 20191 | MGI:99685 | MOUSE11775 | ||
| 49090 | FB:FBgn0011286 | |||
| 179080 | WB:WBGene00006801 | |||
| 396856 | PIGXX07478 | |||
| 403615 | CANLF14522 | |||
| 457846 | 9598_0:0006c1 | PANTR24012 | ||
| 568463 | ZFIN:ZDB-GENE-061226-3 | |||
| 689560 | RGD:620314 | RATNO12911 | ||
| 717179 | MACMU21812 | |||
| 100028207 | MONDO12708 |
