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sortilin 1

Summary

Gene Symbol

SORT1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6272

PubChem

6272

Alliance of Genome Resources

HGNC:11186

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cleavage on pair of basic residues
Developmental protein
Differentiation
Direct protein sequencing
Disulfide bond
Endocytosis
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Lysosome
Nucleus
Osteogenesis
Palmitate
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
Q99523	100 kDa NT receptor Glycoprotein 95 Neurotensin receptor 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
endocytosis	IBA IDA	11331584 21092856
endosome to lysosome transport	IDA	11331584
negative regulation of lipoprotein lipase activity	IDA	10085125
glucose import	IMP	15992544
myotube differentiation	IMP	18258592

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

neurotrophin TRK receptor signaling pathway

neurotrophin signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway via death domain receptors

G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway via death domain receptors

vesicle-mediated transport [inference]

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to endosome transport

Golgi to vacuole transport [inference]

Golgi to lysosome transport

plasma membrane to endosome transport

multivesicular body sorting pathway [inference]

endosome transport via multivesicular body sorting pathway

cellular developmental process [inference]

cell differentiation [inference]

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

myotube differentiation

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

Golgi to vacuole transport [inference]

Golgi to lysosome transport

lysosomal transport [inference]

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway

cytosolic transport [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein localization to vacuole [inference]

protein localization to lysosome [inference]

protein targeting to lysosome

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

glucose transmembrane transport [inference]

glucose import

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization

cell junction organization [inference]

cell junction maintenance [inference]

maintenance of synapse structure

synapse organization [inference]

maintenance of synapse structure

cellular component maintenance [inference]

cell junction maintenance [inference]

maintenance of synapse structure

multicellular organismal process [inference]

ossification

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

myotube differentiation

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein localization to vacuole [inference]

protein localization to lysosome [inference]

protein targeting to lysosome

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to endosome transport

Golgi to vacuole transport [inference]

Golgi to lysosome transport

plasma membrane to endosome transport

multivesicular body sorting pathway [inference]

endosome transport via multivesicular body sorting pathway

intracellular transport [inference]

vacuolar transport [inference]

Golgi to vacuole transport [inference]

Golgi to lysosome transport

lysosomal transport [inference]

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway

cytosolic transport [inference]

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

glucose transmembrane transport [inference]

glucose import

organic substance transport [inference]

carbohydrate transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

glucose transmembrane transport [inference]

glucose import

import into cell [inference]

endocytosis

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

Golgi to vacuole transport [inference]

Golgi to lysosome transport

lysosomal transport [inference]

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway

cytosolic transport [inference]

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

Golgi to vacuole transport [inference]

Golgi to lysosome transport

lysosomal transport [inference]

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway

cytosolic transport [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein localization to vacuole [inference]

protein localization to lysosome [inference]

protein targeting to lysosome

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of fat cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of fat cell differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

negative regulation of fat cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of fat cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

neurotrophin TRK receptor signaling pathway

neurotrophin signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway via death domain receptors

G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway via death domain receptors

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

negative regulation of fat cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of fat cell differentiation

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of lipoprotein lipase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of lipoprotein lipase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of lipoprotein lipase activity

regulation of lipase activity [inference]

regulation of lipoprotein lipase activity [inference]

negative regulation of lipoprotein lipase activity

negative regulation of lipase activity [inference]

negative regulation of lipoprotein lipase activity

Displaying entries **16 - 18** of 18 in total

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GO Term	Evidence Code	PMID
perinuclear region of cytoplasm	IDA	11331584
clathrin-coated pit	IDA	11331584
lysosomal membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

plasma membrane region [inference]

clathrin-coated pit

cell junction [inference]

synapse [inference]

excitatory synapse [inference]

asymmetric, glutamatergic, excitatory synapse [inference]

cerebellar climbing fiber to Purkinje cell synapse

glutamatergic synapse [inference]

asymmetric, glutamatergic, excitatory synapse [inference]

cerebellar climbing fiber to Purkinje cell synapse

neuron to neuron synapse [inference]

asymmetric synapse [inference]

asymmetric, glutamatergic, excitatory synapse [inference]

cerebellar climbing fiber to Purkinje cell synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

early endosome

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle

trans-Golgi network transport vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

early endosome

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle

trans-Golgi network transport vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

early endosome

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle

trans-Golgi network transport vesicle

perinuclear region of cytoplasm

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GO Term	Evidence Code	PMID
protein binding	IPI	10085125 11390366 14985763 16787399 18687776 19122660 20584990 20676133 21092856 21102451 21949853 22431521 23236149 23283322 24070898 24128306 25401472 28541286 32296183 32814053
retromer complex binding	IDA	18817523
neurotensin receptor activity, non-G protein-coupled	IDA	9756851
enzyme binding	IPI	10085125
nerve growth factor receptor activity	IDA	14985763

GO Hierarchy

molecular function

binding [inference]

protein binding

growth factor binding [inference]

neurotrophin binding [inference]

nerve growth factor binding

enzyme binding

protein-containing complex binding [inference]

retromer complex binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

neurotensin receptor activity, non-G protein-coupled

neurotrophin receptor activity [inference]

nerve growth factor receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sortilin

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
InterPro
Sortilin, C-terminal
Sortilin, N-terminal
VPS10
WD40/YVTN repeat-like-containing domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:7693	abdominal aortic aneurysm	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 68 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	855802		SGD:S000005348
Ornithorhynchus anatinus	100073401			ORNAN24084
Xenopus laevis	100158281		Xenbase:XB-GENE-4755068
Callithrix jacchus	100403209			CALJA41862
Pongo abelii	100457993	9601_0:0001a9		PONAB17809
Xenopus tropicalis	100490074		Xenbase:XB-GENE-982637
Nomascus leucogenys	100579848			NOMLE05761
Cavia porcellus	100718269			CAVPO01855
Otolemur garnettii	100947840			OTOGA16638
Pan paniscus	100974043	9597_0:00018d

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements