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sterol-C5-desaturase

Summary

Gene Symbol

SC5D

Aliases

delta(7)-sterol 5(6)-desaturase
lathosterol oxidase

Organism

Homo sapiens (human)

External Links

NCBI Gene

6309

HGNC

10547

KEGG Gene ID

hsa:6309

PubChem

6309

Alliance of Genome Resources

HGNC:10547

Annotation

Keyword

Disease variant
Endoplasmic reticulum
Iron
Oxidoreductase
Phosphoprotein
Reference proteome
Sterol biosynthesis
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O75845	C-5 sterol desaturase Delta(7)-sterol 5-desaturase Delta(7)-sterol C5(6)-desaturase Lathosterol 5-desaturase Sterol-C5-desaturase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cholesterol biosynthetic process via desmosterol
negative regulation of ferroptosis	IMP	38297129 38297130
cholesterol biosynthetic process via lathosterol	IBA IDA TAS	10786622

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of cellular process [inference]

regulation of programmed cell death [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of ferroptosis [inference]

negative regulation of ferroptosis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	IBA
endoplasmic reticulum membrane	IDA TAS	10786622

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
delta7-sterol 5(6)-desaturase activity	IDA	10786622
C-5 sterol desaturase activity	EXP IBA	12189593 12812989
iron ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [inference]

sterol desaturase activity [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Fatty acid hydroxylase domain-containing protein

Functional Category

C: Energy production and conversion
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 4** entries
Gene Ontology
C-4 methylsterol oxidase activity
iron ion binding
lipid biosynthetic process
oxidoreductase activity

Displaying 1 entry
InterPro
Fatty acid hydroxylase

Human Protein Atlas

ENSG00000109929

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)