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stearoyl-CoA desaturase

Summary

Gene Symbol

Aliases

FADS5
SCD1
acyl-CoA desaturase
delta-9-desaturase
fatty acid desaturase

Organism

Homo sapiens (human)

External Links

NCBI Gene

6319

HGNC

10571

KEGG Gene ID

hsa:6319

PubChem

6319

Alliance of Genome Resources

HGNC:10571

Annotation

Keyword

3D-structure
Direct protein sequencing
Endoplasmic reticulum
Fatty acid biosynthesis
Iron
Metal-binding
Oxidoreductase
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O00767	Acyl-CoA desaturase Delta(9)-desaturase Fatty acid desaturase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
monounsaturated fatty acid biosynthetic process	IBA
response to fatty acid	IBA
unsaturated fatty acid biosynthetic process	IBA IDA	15907797 18765284
positive regulation of cold-induced thermogenesis	ISS	15210843 19429677

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process

monounsaturated fatty acid metabolic process [inference]

monounsaturated fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process

monounsaturated fatty acid metabolic process [inference]

monounsaturated fatty acid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process

monounsaturated fatty acid metabolic process [inference]

monounsaturated fatty acid biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process

monounsaturated fatty acid metabolic process [inference]

monounsaturated fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process

monounsaturated fatty acid metabolic process [inference]

monounsaturated fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process

monounsaturated fatty acid metabolic process [inference]

monounsaturated fatty acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process

monounsaturated fatty acid metabolic process [inference]

monounsaturated fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process

monounsaturated fatty acid metabolic process [inference]

monounsaturated fatty acid biosynthetic process

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to lipid [inference]

response to fatty acid

response to oxygen-containing compound [inference]

response to fatty acid

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA
endoplasmic reticulum membrane	IBA IDA TAS	15907797
membrane	HDA IDA	18765284 19946888
nucleolus	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
palmitoyl-CoA 9-desaturase activity	IBA
oxidoreductase activity	IDA	15907797 18765284
iron ion binding	IBA IDA	18765284
protein binding	IPI	30177828 32296183
stearoyl-CoA 9-desaturase activity	IBA IDA	15907797 18765284

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [inference]

acyl-CoA desaturase activity [inference]

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000099194

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00507

Name

stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1]

References

Rhea

RHEA:19721

H⁺ + O₂ + octadecanoyl-CoA

H₂O + (9Z)-octadecenoyl-CoA

Enzyme

1.14.19.1

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of **258** in total

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DO ID	Disease Name	Source
DOID:0014667	disease of metabolism	DisGeNET
DOID:0050387	nonpapillary renal cell carcinoma	DisGeNET
DOID:0050451	Brugada syndrome	DisGeNET
DOID:0050657	Bannayan-Riley-Ruvalcaba syndrome	DisGeNET
DOID:0050664	Bietti crystalline corneoretinal dystrophy	DisGeNET
DOID:0050700	cardiomyopathy	DisGeNET DisGeNET
DOID:0050782	Zollinger-Ellison syndrome	DisGeNET
DOID:0050848	obstructive sleep apnea	DisGeNET
DOID:0060041	autism spectrum disorder	DisGeNET
DOID:0060173	Timothy syndrome	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000983
Gene Name: stearoyl-CoA desaturase (delta-9-desaturase)

Ortholog

Displaying entries **1 - 10** of 60 in total

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Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	178122	WB:WBGene00001398
Caenorhabditis elegans	179100	WB:WBGene00001399
Caenorhabditis elegans	180162	WB:WBGene00001397
Drosophila melanogaster	41536	FB:FBgn0043043
Drosophila melanogaster	43591	FB:FBgn0039754
Drosophila melanogaster	43592	FB:FBgn0039755
Drosophila melanogaster	43593	FB:FBgn0039756
Drosophila melanogaster	117369	FB:FBgn0086687
Danio rerio	386661	ZFIN:ZDB-GENE-031106-3
Danio rerio	553734	ZFIN:ZDB-GENE-050522-12

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements