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MIRAGE
C-C motif chemokine ligand 5
Summary
- Gene Symbol
-
- CCL5
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Chemotaxis
- Cytokine
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Inflammatory response
- Oxidation
- Proteomics identification
- Reference proteome
- Secreted
- Signal
- Proteins
| UniProt | Protein Name |
|---|---|
| D0EI67 |
|
| P13501 |
|
| A0A494C1Q1 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| dendritic cell chemotaxis | ||
| monocyte chemotaxis | ||
| regulation of chronic inflammatory response | ||
| calcium ion transport | ||
| intracellular calcium ion homeostasis |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of signaling [inference]
regulation of locomotion [inference]
positive regulation of locomotion [inference]
regulation of chemotaxis [inference]
regulation of cell motility [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of signaling [inference]
positive regulation of locomotion [inference]
positive regulation of cellular process [inference]
positive regulation of response to stimulus [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of signal transduction [inference]
regulation of response to external stimulus [inference]
positive regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of cell population proliferation [inference]
regulation of programmed cell death [inference]
positive regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of cell motility [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular space | ||
| extracellular space | ||
| cytoplasm |
| GO Term | Evidence Code | PMID |
|---|---|---|
| phosphatidylinositol phospholipase C activity | ||
| protein kinase activity | ||
| protein binding | ||
| chemokine activity | ||
| chemokine activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- C chemokine
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| cell chemotaxis |
| chemokine activity |
| chemotaxis |
| cytokine activity |
| immune response |
| positive regulation of T cell chemotaxis |
| InterPro |
|---|
| CC chemokine, conserved site |
| Chemokine beta/gamma/delta |
| Chemokine interleukin-8-like domain |
| Chemokine interleukin-8-like superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:1883 | hepatitis C | |
| DOID:2043 | hepatitis B | |
| DOID:2841 | asthma | |
| DOID:2945 | severe acute respiratory syndrome | |
| DOID:2957 | pulmonary tuberculosis | |
| DOID:4989 | pancreatitis | |
| DOID:5082 | liver cirrhosis | |
| DOID:526 | human immunodeficiency virus infectious disease | |
| DOID:684 | hepatocellular carcinoma | |
| DOID:9744 | type 1 diabetes mellitus |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 6347 | ZFIN:ZDB-GENE-081022-33 | ||
| 6352 | Xenbase:XB-GENE-983507 | ||
| 6356 | ZFIN:ZDB-GENE-081022-33 | ||
| 6358 | ZFIN:ZDB-GENE-081022-33 | ||
| 20292 | ZFIN:ZDB-GENE-081022-33 |
