succinate dehydrogenase complex flavoprotein subunit A

Summary
Gene Symbol
  • SDHA
Aliases
  • FP
  • SDHF
  • flavoprotein subunit of complex II
  • succinate dehydrogenase [ubiquinone] flavoprotein subunit
Organism
Homo sapiens (human)
External Links
NCBI Gene
6389
HGNC
10680
KEGG Gene ID
hsa:6389
PubChem
6389
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Cardiomyopathy
  • Direct protein sequencing
  • Disease variant
  • Electron transport
  • FAD
  • Leigh syndrome
  • Membrane
  • Mitochondrion inner membrane
  • Neurodegeneration
  • Oxidoreductase
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Transit peptide
  • Tricarboxylic acid cycle
  • Tumor suppressor
Proteins
Displaying all 2 entries
UniProt Protein Name
P31040
  • Flavoprotein subunit of complex II
  • Malate dehydrogenase [quinone] flavoprotein subunit
D6RFM5
Gene Ontology (GO)
GO Hierarchy
GO Hierarchy
Human Protein Atlas
ENSG00000073578

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K00234
Name
succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1]
References
Disease
Disease Ontology
Displaying entries 1 - 10 of 198 in total
DO ID Disease Name Source
DOID:0050387 nonpapillary renal cell carcinoma
DOID:0050424 familial adenomatous polyposis
DOID:0050428 nonepidermolytic palmoplantar keratoderma
DOID:0050486 exanthem
DOID:0050572 cone-rod dystrophy
DOID:0050700 cardiomyopathy
DOID:0050754 ataxia with oculomotor apraxia type 1
DOID:0050771 pheochromocytoma
DOID:0050773 paraganglioma
DOID:0050841 focal hand dystonia
The Human Phenotype Ontology
Displaying entries 1 - 10 of 164 in total
HPO ID HPO Term
HP:0000006 Autosomal dominant inheritance
HP:0000007 Autosomal recessive inheritance
HP:0000076 Vesicoureteral reflux
HP:0000093 Proteinuria
HP:0000096 Glomerular sclerosis
HP:0000405 Conductive hearing impairment
HP:0000407 Sensorineural hearing impairment
HP:0000478 Abnormality of the eye
HP:0000505 Visual impairment
HP:0000508 Ptosis
Displaying all 8 entries
Disease ID Disease Name
ORPHA:154
  • dilated cardiomyopathy 1KK
  • obsolete familial isolated dilated cardiomyopathy
OMIM:613642
  • dilated cardiomyopathy 1GG
ORPHA:3208
  • mitochondrial complex II deficiency, nuclear type 1
ORPHA:44890
  • gastrointestinal stromal tumor
ORPHA:29072
  • hereditary pheochromocytoma-paraganglioma
OMIM:252011
  • mitochondrial complex II deficiency, nuclear type 1
OMIM:619259
  • neurodegeneration with ataxia and late-onset optic atrophy
OMIM:614165
  • paragangliomas 5

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Last updated: August 19, 2024