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glycogen phosphorylase L

Summary

Gene Symbol

Pygl

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

64035

PubChem

64035

Alliance of Genome Resources

RGD:620687

Annotation

Keyword

Acetylation
Allosteric enzyme
Cytoplasm
Glycogen metabolism
Glycosyltransferase
Nucleotide-binding
Phosphoprotein
Pyridoxal phosphate
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6HBY8
P09811

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
5-phosphoribose 1-diphosphate biosynthetic process	IMP	15571236

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

biosynthetic process [inference]

organic substance biosynthetic process [inference]

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

5-phosphoribose 1-diphosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

5-phosphoribose 1-diphosphate biosynthetic process

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

glycogen catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

ribose phosphate metabolic process [inference]

ribose phosphate biosynthetic process [inference]

5-phosphoribose 1-diphosphate biosynthetic process

5-phosphoribose 1-diphosphate metabolic process [inference]

5-phosphoribose 1-diphosphate biosynthetic process

organophosphate metabolic process [inference]

ribose phosphate metabolic process [inference]

ribose phosphate biosynthetic process [inference]

5-phosphoribose 1-diphosphate biosynthetic process

5-phosphoribose 1-diphosphate metabolic process [inference]

5-phosphoribose 1-diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

5-phosphoribose 1-diphosphate biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process

glycogen catabolic process

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process

glycogen catabolic process

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

organophosphate metabolic process [inference]

ribose phosphate metabolic process [inference]

ribose phosphate biosynthetic process [inference]

5-phosphoribose 1-diphosphate biosynthetic process

5-phosphoribose 1-diphosphate metabolic process [inference]

5-phosphoribose 1-diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

5-phosphoribose 1-diphosphate biosynthetic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process

glycogen catabolic process

glucan catabolic process [inference]

glycogen catabolic process

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribose phosphate biosynthetic process [inference]

5-phosphoribose 1-diphosphate biosynthetic process

5-phosphoribose 1-diphosphate metabolic process [inference]

5-phosphoribose 1-diphosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

5-phosphoribose 1-diphosphate biosynthetic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

organic substance biosynthetic process [inference]

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

5-phosphoribose 1-diphosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

5-phosphoribose 1-diphosphate biosynthetic process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

programmed necrotic cell death [inference]

necroptotic process

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

glycogen catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

ribose phosphate metabolic process [inference]

ribose phosphate biosynthetic process [inference]

5-phosphoribose 1-diphosphate biosynthetic process

5-phosphoribose 1-diphosphate metabolic process [inference]

5-phosphoribose 1-diphosphate biosynthetic process

organophosphate metabolic process [inference]

ribose phosphate metabolic process [inference]

ribose phosphate biosynthetic process [inference]

5-phosphoribose 1-diphosphate biosynthetic process

5-phosphoribose 1-diphosphate metabolic process [inference]

5-phosphoribose 1-diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

5-phosphoribose 1-diphosphate biosynthetic process

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	IEA
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
vitamin binding	ISO
purine nucleobase binding	ISO
AMP binding	ISO
SHG alpha-glucan phosphorylase activity
identical protein binding	IPI ISO	1554349

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

1,4-alpha-oligoglucan phosphorylase activity

glycogen phosphorylase activity

binding [inference]

protein binding [inference]

identical protein binding

carbohydrate binding

monosaccharide binding [inference]

glucose binding

small molecule binding [inference]

vitamin binding

vitamin B6 binding [inference]

pyridoxal phosphate binding

organic acid binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

bile acid binding

monosaccharide binding [inference]

glucose binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

nucleobase binding [inference]

purine nucleobase binding

vitamin B6 binding [inference]

pyridoxal phosphate binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

bile acid binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

AMP binding

organic cyclic compound binding [inference]

nucleobase binding [inference]

purine nucleobase binding

vitamin B6 binding [inference]

pyridoxal phosphate binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

glycogen phosphorylase, liver form

Functional Category

G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 10** entries
Gene Ontology
1,4-alpha-oligoglucan phosphorylase activity
SHG alpha-glucan phosphorylase activity
catalytic activity
glycogen catabolic process
glycogen metabolic process
glycogen phosphorylase activity
linear malto-oligosaccharide phosphorylase activity
nucleotide binding
pyridoxal phosphate binding
transferase activity

Displaying **all 3** entries
InterPro
Glycogen/starch/alpha-glucan phosphorylase
Glycosyl transferase, family 35
Phosphorylase pyridoxal-phosphate attachment site

Rhea

phosphate

α-D-glucose 1-phosphate

Enzyme

2.4.1.1

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:2747	glycogen storage disease	Alliance of Genome Resources
DOID:2754	glycogen storage disease VI	Alliance of Genome Resources
DOID:3650	lactic acidosis	Alliance of Genome Resources

Ortholog

Displaying entries **101 - 110** of **114** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Panthera leo	122222627			PANLE19418
Ursus americanus	123793149			URSAM10053
Marmota monax	124104267	9995_0:002712
Sciurus carolinensis	124976720	30640_0:000ba3
Perognathus longimembris pacificus	125363175	214514_0:00351b
Myodes glareolus	125387694	447135_0:003a5a
Microtus fortis	126508346	100897_0:002669
Acomys russatus	127190048	60746_0:000168
Phodopus roborovskii	127230657	109678_0:003311
Apodemus sylvaticus	127687267	10129_0:0022e0

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024