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xylosyltransferase 1

Summary

Gene Symbol

XYLT1

Aliases

PXYLT1
XT-I
protein xylosyltransferase 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

64131

GGDB ID

gg169

HGNC

15516

mRNA

NM_022166

map

16p12

Protein

NP_071449

OMIM

608124

KEGG Gene ID

hsa:64131

PubChem

64131

Alliance of Genome Resources

HGNC:15516

Annotation

Keyword

3D-structure
Direct protein sequencing
Disease variant
Disulfide bond
Dwarfism
Glycoprotein
Glycosyltransferase
Golgi apparatus
Metal-binding
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q86Y38	Peptide O-xylosyltransferase 1 Xylosyltransferase I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
embryonic skeletal system development	ISS
glycosaminoglycan metabolic process	TAS
chondroitin sulfate proteoglycan biosynthetic process	IBA IMP	17189265
glycosaminoglycan biosynthetic process	TAS	11099377
ossification involved in bone maturation	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

glycosaminoglycan metabolic process

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

sulfur compound biosynthetic process [inference]

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

sulfur compound biosynthetic process [inference]

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

glycosaminoglycan metabolic process

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

glycosaminoglycan metabolic process

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

glycosaminoglycan metabolic process

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

chondroitin sulfate biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process

sulfur compound biosynthetic process [inference]

multicellular organismal process [inference]

ossification [inference]

ossification involved in bone maturation

developmental process [inference]

anatomical structure development [inference]

system development [inference]

skeletal system development [inference]

embryonic skeletal system development

Displaying **all 3** entries
GO Term	Evidence Code	PMID
Golgi cis cisterna	ISS
Golgi membrane	IDA TAS	16571645
extracellular space	IDA	11087729

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi cisterna [inference]

Golgi cis cisterna

Displaying **all 2** entries
GO Term	Evidence Code	PMID
metal ion binding	IEA
protein xylosyltransferase activity	IBA IDA TAS	11087729 11099377 17189265 29681470

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

UDP-xylosyltransferase activity [inference]

protein xylosyltransferase activity

pentosyltransferase activity [inference]

xylosyltransferase activity [inference]

UDP-xylosyltransferase activity [inference]

protein xylosyltransferase activity

catalytic activity, acting on a protein [inference]

protein xylosyltransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
transferase activity

GlycoGene Database (GGDB)

GGDB ID

gg169

Gene Symbol

XYLT1

Orthologous Gene

Displaying **all 3** entries
Species	Protein	mRNA
Drosophila melanogaster	NP_647705	NM_139448
Rattus norvegicus	XP_341913	XM_341912
Mus musculus	NP_783576	NM_175645

KEGG BRITE Database

Orthology

K00771

Name

protein xylosyltransferase [EC:2.4.2.26]

References

11099377

Rhea

RHEA:50192

UDP-α-D-xylose

H⁺ + UDP

Enzyme

2.4.2.26

PMID

Disease

The Human Phenotype Ontology

Displaying entries **31 - 40** of **106** in total

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HPO ID	HPO Term
HP:0000944	Abnormal metaphysis morphology
HP:0000954	Single transverse palmar crease
HP:0000973	Cutis laxa
HP:0001007	Hirsutism
HP:0001027	Soft, doughy skin
HP:0001061	Acne
HP:0001102	Angioid streaks of the fundus
HP:0001249	Intellectual disability
HP:0001252	Hypotonia
HP:0001263	Global developmental delay

Displaying **all 4** entries
Disease ID	Disease Name
OMIM:615777	Desbuquois dysplasia 2
OMIM:264800	autosomal recessive inherited pseudoxanthoma elasticum
ORPHA:1425	Desbuquois dysplasia
ORPHA:370930	XYLT1-congenital disorder of glycosylation

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 39 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	38288		FB:FBgn0015360
Rattus norvegicus	64133		RGD:620093	RATNO21273
Caenorhabditis elegans	190099		WB:WBGene00005024
Mus musculus	233781		MGI:2451073	MOUSE55236
Xenopus laevis	444363		Xenbase:XB-GENE-949402
Pan troglodytes	453955	9598_0:00412d		PANTR11841
Bos taurus	541295			BOVIN20351
Danio rerio	560951		ZFIN:ZDB-GENE-111017-2
Ciona intestinalis	619275			CIOIN06429
Macaca mulatta	718187			MACMU27524

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements