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xylosyltransferase 2

Summary

Gene Symbol

XYLT2

Aliases

PXYLT2
XT-II
protein xylosyltransferase 2

Organism

Homo sapiens (human)

External Links

NCBI Gene

64132

GGDB ID

gg170

HGNC

15517

mRNA

NM_022167

map

17q21.3-17q22

Protein

NP_071450

OMIM

608125

KEGG Gene ID

hsa:64132

PubChem

64132

Alliance of Genome Resources

HGNC:15517

Annotation

Keyword

Alternative splicing
Disease variant
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Magnesium
Manganese
Membrane
Metal-binding
Proteomics identification
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9H1B5	Peptide O-xylosyltransferase 1 Xylosyltransferase II
B4DT06	Xylosyltransferase II

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
chondroitin sulfate biosynthetic process	IEA
heparan sulfate proteoglycan biosynthetic process	IBA IEA IMP	17189265 26027496
chondroitin sulfate proteoglycan biosynthetic process	IBA IMP	17189265 26027496
glycosaminoglycan metabolic process	TAS
glycosaminoglycan biosynthetic process	NAS	11099377

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycosaminoglycan metabolic process

glycosaminoglycan biosynthetic process

mucopolysaccharide metabolic process [inference]

heparin metabolic process [inference]

heparin biosynthetic process

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

sulfur compound biosynthetic process [inference]

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

heparin metabolic process [inference]

heparin biosynthetic process

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

sulfur compound biosynthetic process [inference]

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycosaminoglycan metabolic process

glycosaminoglycan biosynthetic process

mucopolysaccharide metabolic process [inference]

heparin metabolic process [inference]

heparin biosynthetic process

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycosaminoglycan metabolic process

glycosaminoglycan biosynthetic process

mucopolysaccharide metabolic process [inference]

heparin metabolic process [inference]

heparin biosynthetic process

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycosaminoglycan metabolic process

glycosaminoglycan biosynthetic process

mucopolysaccharide metabolic process [inference]

heparin metabolic process [inference]

heparin biosynthetic process

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

heparin metabolic process [inference]

heparin biosynthetic process

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

sulfur compound biosynthetic process [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular space	IDA	25748573
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein xylosyltransferase activity	IBA IDA NAS TAS	11099377 17189265 18023272 25748573
magnesium ion binding	IDA	18023272
manganese ion binding	IDA	18023272

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

UDP-xylosyltransferase activity [inference]

protein xylosyltransferase activity

pentosyltransferase activity [inference]

xylosyltransferase activity [inference]

UDP-xylosyltransferase activity [inference]

protein xylosyltransferase activity

catalytic activity, acting on a protein [inference]

protein xylosyltransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

transition metal ion binding [inference]

manganese ion binding

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg170

Gene Symbol

XYLT2

Orthologous Gene

Displaying **all 3** entries
Species	Protein	mRNA
Rattus norvegicus	NP_071632	NM_022296
Caenorhabditis elegans	AAO85277	AY241928
Mus musculus	CAC185567	AJ291751

KEGG BRITE Database

Orthology

K00771

Name

protein xylosyltransferase [EC:2.4.2.26]

References

11099377

Rhea

RHEA:50192

UDP-α-D-xylose

H⁺ + UDP

Enzyme

2.4.2.26

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:2921	glomerulonephritis	DisGeNET
DOID:2962	Cockayne syndrome	DisGeNET
DOID:3165	skin benign neoplasm	DisGeNET
DOID:3369	Ewing sarcoma	DisGeNET
DOID:3490	Noonan syndrome	DisGeNET
DOID:3523	brain stem infarction	DisGeNET
DOID:3526	cerebral infarction	DisGeNET DisGeNET
DOID:3669	intermittent claudication	DisGeNET
DOID:397	restrictive cardiomyopathy	DisGeNET
DOID:4007	bladder carcinoma	DisGeNET DisGeNET

The Human Phenotype Ontology

Displaying entries **11 - 20** of 76 in total

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HPO ID	HPO Term
HP:0000465	Webbed neck
HP:0000470	Short neck
HP:0000505	Visual impairment
HP:0000518	Cataract
HP:0000534	Abnormal eyebrow morphology
HP:0000541	Retinal detachment
HP:0000545	Myopia
HP:0000568	Microphthalmia
HP:0000572	Visual loss
HP:0000573	Retinal hemorrhage

Displaying **all 3** entries
Disease ID	Disease Name
ORPHA:85194	spondylo-ocular syndrome
OMIM:605822	spondylo-ocular syndrome
OMIM:264800	autosomal recessive inherited pseudoxanthoma elasticum

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	190099	WB:WBGene00005024
Drosophila melanogaster	38288	FB:FBgn0015360
Ciona intestinalis	619275		CIOIN06429
Danio rerio	563446	ZFIN:ZDB-GENE-081022-125
Xenopus laevis	108701100	Xenbase:XB-GENE-6486005
Xenopus tropicalis	448400	Xenbase:XB-GENE-993408
Cercocebus atys	105579440		CERAT29321
Macaca fascicularis	102133732		MACFA13710
Macaca nemestrina	105472374		MACNE31522
Papio anubis	101013908		PAPAN13271

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements