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endoplasmic reticulum aminopeptidase 2

Summary

Gene Symbol

ERAP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

64167

PubChem

64167

Alliance of Genome Resources

HGNC:29499

Annotation

Keyword

3D-structure
Adaptive immunity
Alternative splicing
Aminopeptidase
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6P179	Leukocyte-derived arginine aminopeptidase
B2R769

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
adaptive immune response	IEA
antigen processing and presentation of peptide antigen via MHC class I	TAS
proteolysis	IBA
regulation of blood pressure	TAS	12799365
antigen processing and presentation of endogenous peptide antigen via MHC class I	TAS	15691326

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

antigen processing and presentation [inference]

antigen processing and presentation of endogenous antigen [inference]

antigen processing and presentation of endogenous peptide antigen [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of peptide antigen via MHC class I

antigen processing and presentation of endogenous peptide antigen via MHC class I

antigen processing and presentation of endogenous peptide antigen [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

protein metabolic process [inference]

proteolysis

organonitrogen compound catabolic process [inference]

peptide catabolic process

catabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

protein metabolic process [inference]

proteolysis

organonitrogen compound catabolic process [inference]

peptide catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

response to stimulus [inference]

immune response [inference]

adaptive immune response

biological regulation [inference]

regulation of biological quality [inference]

regulation of blood pressure

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GO Term	Evidence Code	PMID
extracellular space	IBA
cytoplasm	IBA
endoplasmic reticulum lumen	TAS	15691326
endoplasmic reticulum lumen	IDA	12799365
endoplasmic reticulum membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

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GO Term	Evidence Code	PMID
endopeptidase activity	EXP	12436109 12436110 17088086
aminopeptidase activity	IDA	12799365
protein binding	IPI	15908954
metallopeptidase activity	IDA	12799365
zinc ion binding	TAS	12799365

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

metallopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloaminopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

metallopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloaminopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

binding [inference]

protein binding

amide binding [inference]

peptide binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

aminopeptidase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 9** entries
Gene Ontology
aminopeptidase activity
hydrolase activity
metal ion binding
metalloaminopeptidase activity
metallopeptidase activity
peptide binding
peptide catabolic process
proteolysis
zinc ion binding

Displaying **all 7** entries
InterPro
Aminopeptidase N-like , N-terminal domain superfamliy
Aminopeptidase N-like , N-terminal domain
Aminopeptidase N-type
ERAP1-like C-terminal domain
Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
Peptidase M1, membrane alanine aminopeptidase
Peptidase M4/M1, CTD superfamily

Ortholog

Displaying entries **1 - 10** of 60 in total

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Species	Gene ID	Alliance of Genome Resources
Saccharomyces cerevisiae S288C	290	SGD:S000001399
Saccharomyces cerevisiae S288C	2028	SGD:S000001399
Saccharomyces cerevisiae S288C	4012	SGD:S000001399
Saccharomyces cerevisiae S288C	13809	SGD:S000001399
Saccharomyces cerevisiae S288C	16790	SGD:S000001399
Saccharomyces cerevisiae S288C	29953	SGD:S000001399
Saccharomyces cerevisiae S288C	51752	SGD:S000001399
Saccharomyces cerevisiae S288C	64017	SGD:S000001399
Danio rerio	64167	ZFIN:ZDB-GENE-080402-6
Saccharomyces cerevisiae S288C	80898	SGD:S000001399

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OrthoDB (Group)

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Acknowledgements