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ATP binding cassette subfamily G member 5

Summary

Gene Symbol

ABCG5

Organism

Homo sapiens (human)

External Links

NCBI Gene

64240

PubChem

64240

Alliance of Genome Resources

HGNC:13886

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell membrane
Disease variant
Glycoprotein
Lipid transport
Magnesium
Metal-binding
Reference proteome
Translocase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9H222	Sterolin-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
response to ionizing radiation	IEA
triglyceride homeostasis	IEA
negative regulation of intestinal phytosterol absorption	IMP	11099417
intestinal cholesterol absorption	IC	12208868
response to xenobiotic stimulus	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

bile acid signaling pathway

transmembrane transport

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

acylglycerol homeostasis [inference]

triglyceride homeostasis

sterol homeostasis [inference]

cholesterol homeostasis

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to abiotic stimulus [inference]

response to radiation [inference]

response to ionizing radiation

response to activity [inference]

response to muscle activity

response to chemical [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

transmembrane transport

organic substance transport [inference]

lipid transport [inference]

sterol transport

cholesterol transport [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organic hydroxy compound transport [inference]

sterol transport

cholesterol transport [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

regulation of sterol transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

regulation of cholesterol transport [inference]

regulation of intestinal cholesterol absorption [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

regulation of intestinal lipid absorption [inference]

regulation of intestinal cholesterol absorption [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

regulation of intestinal absorption [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

regulation of intestinal lipid absorption [inference]

regulation of intestinal cholesterol absorption [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

regulation of lipid localization [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

regulation of sterol transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

regulation of cholesterol transport [inference]

regulation of intestinal cholesterol absorption [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

regulation of intestinal lipid absorption [inference]

regulation of intestinal cholesterol absorption [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

negative regulation of biological process [inference]

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of digestive system process [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

regulation of cellular process [inference]

signal transduction [inference]

bile acid signaling pathway

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of digestive system process [inference]

negative regulation of digestive system process [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

regulation of intestinal absorption [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

regulation of intestinal lipid absorption [inference]

regulation of intestinal cholesterol absorption [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of digestive system process [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
apical plasma membrane	IBA IMP ISS	14504269
receptor complex	IDA	14504269
plasma membrane	IBA ISS TAS
ATP-binding cassette (ABC) transporter complex	IBA IDA	16893193 27144356

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

ATP-binding cassette (ABC) transporter complex

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

ATP-binding cassette (ABC) transporter complex

transporter complex [inference]

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

ATP-binding cassette (ABC) transporter complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	16870176 17474147 27144356
ABC-type transporter activity	IEA
cholesterol transfer activity	IGI	14504269
ATP hydrolysis activity	IDA	16893193
protein heterodimerization activity	IPI	16870176

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity [inference]

sterol transporter activity [inference]

sterol transfer activity [inference]

cholesterol transfer activity

lipid transfer activity [inference]

sterol transfer activity [inference]

cholesterol transfer activity

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

binding [inference]

protein binding

protein dimerization activity [inference]

protein heterodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ATP-binding cassette

Functional Category

J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter family G domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
ABC-2 type transporter, transmembrane domain
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0080208	metabolic dysfunction-associated steatotic liver disease	Alliance of Genome Resources
DOID:0090019	sitosterolemia	Alliance of Genome Resources
DOID:13580	cholestasis	Alliance of Genome Resources
DOID:2349	arteriosclerosis	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 76 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	27409		MGI:1351659	MOUSE22347
Drosophila melanogaster	42976		FB:FBgn0039244
Rattus norvegicus	114628		RGD:620298	RATNO35105
Caenorhabditis elegans	174078		WB:WBGene00016973
Pan troglodytes	459190	9598_0:000bcb		PANTR27509
Canis lupus familiaris	481354			CANLF01796
Bos taurus	515536			BOVIN02312
Danio rerio	557317		ZFIN:ZDB-GENE-050517-40	DANRE05798
Macaca mulatta	713610			MACMU07773
Monodelphis domestica	100033373			MONDO08469

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements