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hedgehog interacting protein

Summary

Gene Symbol

HHIP

Organism

Homo sapiens (human)

External Links

NCBI Gene

64399

PubChem

64399

Alliance of Genome Resources

HGNC:14866

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cytoplasm
Disulfide bond
EGF-like domain
Glycoprotein
Metal-binding
Reference proteome
Repeat
Secreted
Signal
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96QV1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
signal transduction	IEA
neuroblast proliferation	IEA
dorsal/ventral pattern formation	IEA
negative regulation of signal transduction	IDA	19561609
regulation of fibroblast growth factor receptor signaling pathway	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cell population proliferation [inference]

neural precursor cell proliferation [inference]

neuroblast proliferation

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation

developmental process [inference]

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

animal organ morphogenesis [inference]

skeletal system morphogenesis

tube morphogenesis [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction

negative regulation of smoothened signaling pathway

regulation of fibroblast growth factor receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction

negative regulation of smoothened signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction

negative regulation of smoothened signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of smoothened signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of response to stimulus [inference]

negative regulation of signal transduction

negative regulation of smoothened signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction

negative regulation of smoothened signaling pathway

regulation of fibroblast growth factor receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction

negative regulation of smoothened signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of fibroblast growth factor receptor signaling pathway

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction

negative regulation of smoothened signaling pathway

regulation of fibroblast growth factor receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of smoothened signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of smoothened signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
cytoplasm	IEA
plasma membrane	ISS	11435703
cell surface	IEA
ciliary membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

ciliary membrane

plasma membrane region [inference]

cell projection membrane [inference]

ciliary membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	19561609 19561611
zinc ion binding	IDA	19561609
hedgehog family protein binding	IPI	19561611

GO Hierarchy

molecular function

binding [inference]

protein binding

hedgehog family protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

HHIP

Functional Category

C: Energy production and conversion
G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism

Displaying **all 3** entries
InterPro
Glucose/Sorbosone dehydrogenase
Six-bladed beta-propeller, TolB-like
Soluble quinoprotein glucose/sorbosone dehydrogenase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3083	chronic obstructive pulmonary disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 75 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	15245	Xenbase:XB-GENE-487499	MOUSE57721
Xenopus tropicalis	64399	Xenbase:XB-GENE-487499
Rattus norvegicus	291936		RATNO15307
Danio rerio	326102		DANRE16843
Pan troglodytes	461521		PANTR34570
Bos taurus	540830		BOVIN09121
Macaca mulatta	701205		MACMU35928
Monodelphis domestica	100019071		MONDO28198
Equus caballus	100062868		HORSE28232
Ornithorhynchus anatinus	100082746		ORNAN03925

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements