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Guidelines

MIRAGE

thimet oligopeptidase 1

Summary

Gene Symbol

Thop1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

64517

PubChem

64517

Alliance of Genome Resources

RGD:68330

Annotation

Keyword

Acetylation
Cytoplasm
Direct protein sequencing
Metal-binding
Metalloprotease
Phosphoprotein
Reference proteome
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P24155	Endo-oligopeptidase A Endopeptidase 24.15 PZ-peptidase Soluble metallo-endopeptidase
A6K8C9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
proteolysis	TAS	11177571
proteolysis	IBA
proteolysis	IEA
peptide metabolic process	ISO
peptide metabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process

peptide catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process

peptide catabolic process

protein metabolic process [inference]

proteolysis

organonitrogen compound catabolic process [inference]

peptide catabolic process

catabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

peptide metabolic process

peptide catabolic process

protein metabolic process [inference]

proteolysis

organonitrogen compound catabolic process [inference]

peptide catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytoplasm	IEA
mitochondrial intermembrane space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
metalloendopeptidase activity	ISO
metalloendopeptidase activity	TAS	11177571
metalloendopeptidase activity	IBA
metalloendopeptidase activity	IEA
peptidase activity	IDA	12500972 8702598

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

amide binding [inference]

peptide binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

peptidase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair

Displaying **all 6** entries
Gene Ontology
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
peptide metabolic process
proteolysis

Displaying **all 4** entries
InterPro
Metallopeptidase, catalytic domain superfamily
Neurolysin/Thimet oligopeptidase, domain 2
Peptidase M3A/M3B catalytic domain
Peptidase M3A/M3B

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7064	Xenbase:XB-GENE-958896	HUMAN39657
Mus musculus	50492	Xenbase:XB-GENE-958896	MOUSE02880
Saccharomyces cerevisiae S288C	57486	SGD:S000000562
Xenopus tropicalis	64517	Xenbase:XB-GENE-958896
Saccharomyces cerevisiae S288C	75805	SGD:S000000562
Sus scrofa	397442		PIGXX18882
Danio rerio	436628		DANRE03018
Canis lupus familiaris	476748		CANLF08056
Macaca mulatta	721578		MACMU18800
Monodelphis domestica	100020499		MONDO18426

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025