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solute carrier family 5 member 2

Summary

Gene Symbol

Slc5a2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

64522

PubChem

64522

Alliance of Genome Resources

RGD:620217

Annotation

Keyword

Cell membrane
Glycoprotein
Reference proteome
Sodium transport
Sugar transport
Symport
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P53792	Low affinity sodium-glucose cotransporter Solute carrier family 5 member 2
Q8R520
Q8R521

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
renal potassium excretion	IMP	29790389
glucose import across plasma membrane	IEA ISO
glucose transmembrane transport	IDA	14506074 7493971
renal glucose absorption	IEA ISO ISS

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

regulation of urine volume [inference]

negative regulation of urine volume

renal absorption [inference]

renal glucose absorption

renal tubular secretion [inference]

renal potassium excretion

excretion [inference]

renal tubular secretion [inference]

renal potassium excretion

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

transmembrane transport

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

organic substance transport [inference]

carbohydrate transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

carbohydrate derivative transport [inference]

glycoside transport [inference]

glucoside transport [inference]

alpha-glucoside transport

import into cell [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

biological regulation [inference]

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of urine volume [inference]

negative regulation of urine volume

Displaying **all 3** entries
GO Term	Evidence Code	PMID
apical plasma membrane	IEA ISO ISS
plasma membrane	IBA IEA ISO
brush border membrane	IDA	14506074

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
alpha-glucoside transmembrane transporter activity	IEA ISO
glucose:sodium symporter activity	IBA IDA IEA ISO	14506074 7493971
D-glucose transmembrane transporter activity	ISO
transmembrane transporter activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

glucose:sodium symporter activity

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

glucose:sodium symporter activity

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

carbohydrate transmembrane transporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

glucose:sodium symporter activity

sugar transmembrane transporter activity [inference]

monosaccharide transmembrane transporter activity [inference]

hexose transmembrane transporter activity [inference]

glucose transmembrane transporter activity [inference]

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

glucose:sodium symporter activity

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

glucose:sodium symporter activity

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

carbohydrate derivative transmembrane transporter activity [inference]

glucoside transmembrane transporter activity [inference]

alpha-glucoside transmembrane transporter activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

sodium/glucose cotransporter 2

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
glucose

Displaying **all 3** entries
InterPro
Sodium/glucose symporter superfamily
Sodium/solute symporter, conserved site
Sodium/solute symporter

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
brush border membrane	PMID:14506074

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:10763	hypertension	Alliance of Genome Resources
DOID:9432	renal glycosuria	Alliance of Genome Resources

Ortholog

Displaying entries **81 - 90** of **100** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Scophthalmus maximus	118299405		SCOMX22791
Onychomys torridus	118588265	38674_0:00000b
Arvicola amphibius	119819738	1047088_0:000656
Microtus oregoni	121457732	111838_0:002a56
Dipodomys spectabilis	122096251	105255_0:0042f5
Panthera leo	122210298		PANLE08625
Ursus americanus	123784688		URSAM29004
Marmota monax	124099432	9995_0:001c9f
Sciurus carolinensis	124970240	30640_0:004e4e
Perognathus longimembris pacificus	125341221	214514_0:0046a6