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solute carrier family 5 member 2

Summary

Gene Symbol

Slc5a2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

64522

PubChem

64522

Alliance of Genome Resources

RGD:620217

Annotation

Keyword

Cell membrane
Glycoprotein
Reference proteome
Sodium transport
Sugar transport
Symport
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P53792	Low affinity sodium-glucose cotransporter Solute carrier family 5 member 2
Q8R520
Q8R521

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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2

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GO Term	Evidence Code	PMID
sodium ion transport	IBA
transmembrane transport	IEA
negative regulation of urine volume	IMP	29790389
sodium ion import across plasma membrane	IEA ISO
alpha-glucoside transport	IEA ISO

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

regulation of urine volume [inference]

negative regulation of urine volume

renal absorption [inference]

renal glucose absorption

renal tubular secretion [inference]

renal potassium excretion

excretion [inference]

renal tubular secretion [inference]

renal potassium excretion

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

transmembrane transport

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

organic substance transport [inference]

carbohydrate transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

carbohydrate derivative transport [inference]

glycoside transport [inference]

glucoside transport [inference]

alpha-glucoside transport

import into cell [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

biological regulation [inference]

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of urine volume [inference]

negative regulation of urine volume

Displaying **all 3** entries
GO Term	Evidence Code	PMID
apical plasma membrane	IEA ISO ISS
plasma membrane	IBA IEA ISO
brush border membrane	IDA	14506074

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
alpha-glucoside transmembrane transporter activity	IEA ISO
glucose:sodium symporter activity	IBA IDA IEA ISO	14506074 7493971
D-glucose transmembrane transporter activity	ISO
transmembrane transporter activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

glucose:sodium symporter activity

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

glucose:sodium symporter activity

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

carbohydrate transmembrane transporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

glucose:sodium symporter activity

sugar transmembrane transporter activity [inference]

monosaccharide transmembrane transporter activity [inference]

hexose transmembrane transporter activity [inference]

glucose transmembrane transporter activity [inference]

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

glucose:sodium symporter activity

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

glucose:sodium symporter activity

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

carbohydrate derivative transmembrane transporter activity [inference]

glucoside transmembrane transporter activity [inference]

alpha-glucoside transmembrane transporter activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

sodium/glucose cotransporter 2

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
glucose

Displaying **all 3** entries
InterPro
Sodium/glucose symporter superfamily
Sodium/solute symporter, conserved site
Sodium/solute symporter

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
brush border membrane	PMID:14506074

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:10763	hypertension	Alliance of Genome Resources
DOID:9432	renal glycosuria	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 60** of **100** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Pteropus vampyrus	105304495		PTEVA02803
Aotus nancymaae	105729261		AOTNA37697
Propithecus coquereli	105807052		PROCO12789
Dipodomys ordii	105982122	10020_0:000e75
Capra hircus	106503577		CAPHI17089
Equus asinus asinus	106831867		EQUAS20639
Marmota marmota marmota	107146989	9994_0:003d72
Sinocyclocheilus grahami	107561374		SINGR81286
Ictalurus punctatus	108277829		ICTPU10799
Rhinopithecus bieti	108527192		RHIBE34024