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MIRAGE
transmembrane serine protease 3
Summary
- Gene Symbol
-
- TMPRSS3
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Alternative splicing
- Autocatalytic cleavage
- Disease variant
- Disulfide bond
- Endoplasmic reticulum
- Glycoprotein
- Non-syndromic deafness
- Reference proteome
- Serine protease
- Signal-anchor
- Transmembrane helix
- Zymogen
- Proteins
| UniProt | Protein Name |
|---|---|
| P57727 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proteolysis | ||
| intracellular sodium ion homeostasis | ||
| sensory perception of sound |
| GO Term | Evidence Code | PMID |
|---|---|---|
| endoplasmic reticulum | ||
| endoplasmic reticulum membrane | ||
| membrane | ||
| neuronal cell body |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| serine-type endopeptidase activity | ||
| sodium channel regulator activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- serine protease
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| hydrolase activity |
| proteolysis |
| serine-type endopeptidase activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110527 | autosomal recessive nonsyndromic deafness 8 | |
| DOID:10003 | sensorineural hearing loss |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 106829955 | EQUAS13382 | ||
| 108238874 | KRYMA13885 | ||
| 108517347 | RHIBE30254 | ||
| 109094176 | CYPCA43933 | ||
| 112908027 | VULVU33660 | ||
| 114029234 | VOMUR24375 | ||
| 117014340 | RHIFE05925 | ||
| 118894670 | BALMU18701 | ||
| 122230092 | PANLE24298 |
