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Submissions

sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1

Summary

Gene Symbol

Svep1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

64817

PubChem

64817

Alliance of Genome Resources

MGI:1928849

Annotation

Keyword

Alternative splicing
Calcium
Cell adhesion
Cytoplasm
Disulfide bond
EGF-like domain
Glycoprotein
Membrane
Nucleus
Reference proteome
Repeat
Secreted
Signal
Sushi

Proteins

Displaying 1 entry
UniProt	Protein Name
A2AVA0	Polydom

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
cell-matrix adhesion	IEA
Tie signaling pathway	IMP	28179430
lymph vessel development	IMP	28179432
positive regulation of platelet activation	IMP ISO	36792666
epidermis development	IBA IMP ISO	27892606

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

cell-cell adhesion [inference]

epithelial cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

Tie signaling pathway

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cell motility [inference]

cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

cell-cell junction organization [inference]

tight junction organization

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

lymph circulation

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

developmental process [inference]

anatomical structure morphogenesis [inference]

lymph vessel morphogenesis

anatomical structure development [inference]

lymph vessel development

tissue development [inference]

epidermis development

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of B cell mediated immunity [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, classical pathway

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of B cell mediated immunity [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

negative regulation of humoral immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, classical pathway

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of B cell mediated immunity [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, classical pathway

regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of B cell mediated immunity [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

regulation of lymphocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of B cell mediated immunity [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

regulation of B cell mediated immunity [inference]

negative regulation of B cell mediated immunity [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

regulation of immunoglobulin mediated immune response [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

regulation of complement activation, classical pathway [inference]

negative regulation of complement activation, classical pathway

regulation of complement activation [inference]

regulation of complement activation, classical pathway [inference]

negative regulation of complement activation, classical pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, classical pathway

regulation of immune response [inference]

regulation of adaptive immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of B cell mediated immunity [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of B cell mediated immunity [inference]

negative regulation of B cell mediated immunity [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

regulation of immunoglobulin mediated immune response [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

regulation of complement activation, classical pathway [inference]

negative regulation of complement activation, classical pathway

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of B cell mediated immunity [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, classical pathway

regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

regulation of complement activation, classical pathway [inference]

negative regulation of complement activation, classical pathway

regulation of complement activation [inference]

regulation of complement activation, classical pathway [inference]

negative regulation of complement activation, classical pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, classical pathway

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of B cell mediated immunity [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

negative regulation of humoral immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, classical pathway

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell activation [inference]

positive regulation of platelet activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of platelet activation

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of B cell mediated immunity [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, classical pathway

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of B cell mediated immunity [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

negative regulation of humoral immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, classical pathway

negative regulation of response to stimulus [inference]

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of B cell mediated immunity [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

negative regulation of humoral immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, classical pathway

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction

regulation of response to stimulus [inference]

negative regulation of response to stimulus [inference]

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of B cell mediated immunity [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

negative regulation of humoral immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, classical pathway

regulation of immune response [inference]

regulation of adaptive immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of B cell mediated immunity [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of B cell mediated immunity [inference]

negative regulation of B cell mediated immunity [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

regulation of immunoglobulin mediated immune response [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

regulation of complement activation, classical pathway [inference]

negative regulation of complement activation, classical pathway

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of B cell mediated immunity [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, classical pathway

regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

regulation of complement activation, classical pathway [inference]

negative regulation of complement activation, classical pathway

regulation of complement activation [inference]

regulation of complement activation, classical pathway [inference]

negative regulation of complement activation, classical pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, classical pathway

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of B cell mediated immunity [inference]

negative regulation of immunoglobulin mediated immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

negative regulation of humoral immune response [inference]

negative regulation of humoral immune response mediated by circulating immunoglobulin [inference]

negative regulation of complement activation, classical pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, classical pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

Tie signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell activation [inference]

positive regulation of platelet activation

regulation of cell activation [inference]

regulation of platelet activation [inference]

positive regulation of platelet activation

positive regulation of cell activation [inference]

positive regulation of platelet activation

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

regulation of cell activation [inference]

regulation of platelet activation [inference]

positive regulation of platelet activation

positive regulation of cell activation [inference]

positive regulation of platelet activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of platelet activation

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular matrix	TAS	28179430
membrane	IEA
extracellular region	IDA ISS	11062057 22654117
extracellular space	HDA IBA IDA	24006456 28179430
nucleus	ISO	27892606

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	28179430 36792666
integrin binding	IMP ISO	28179430
chromatin binding	IDA	15522233
integrin binding involved in cell-matrix adhesion	IDA	22654117
calcium ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

integrin binding involved in cell-matrix adhesion

cell adhesion molecule binding [inference]

integrin binding

integrin binding involved in cell-matrix adhesion

cell adhesion mediator activity [inference]

cell-matrix adhesion mediator activity [inference]

integrin binding involved in cell-matrix adhesion

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

chromatin binding

integrin binding

integrin binding involved in cell-matrix adhesion

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying entries **1 - 10** of 13 in total

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InterPro
Concanavalin A-like lectin/glucanase domain superfamily
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site
Growth factor receptor cysteine-rich domain superfamily
HYR domain
Pentraxin-related
Sushi/SCR/CCP domain
Sushi/SCR/CCP superfamily

Ortholog

Displaying entries **1 - 10** of **114** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	32162		FB:FBgn0001083
Homo sapiens	79987		HGNC:15985	HUMAN98009
Caenorhabditis elegans	188252		WB:WBGene00002976
Pan troglodytes	464652			PANTR44576
Canis lupus familiaris	474799			CANLF02417
Danio rerio	567357		ZFIN:ZDB-GENE-110726-1	DANRE40308
Rattus norvegicus	685899	10116_1:00210e	RGD:1588987	RATNO33877
Macaca mulatta	709478			MACMU12389
Bos taurus	781282			BOVIN35098
Monodelphis domestica	100022943			MONDO28955

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements