ST3 beta-galactoside alpha-2,3-sialyltransferase 1

Summary
Gene Symbol
  • ST3GAL1
Aliases
  • CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase
  • SIATFL
  • ST3Gal I
  • ST3GalA.1
  • ST3O
Organism
Homo sapiens (human)
External Links
NCBI Gene
6482
GGDB ID
HGNC
10862
mRNA
map
  • 8q24.22
Protein
OMIM
KEGG Gene ID
hsa:6482
PubChem
6482
Alliance of Genome Resources
Annotation
Keyword
  • Disulfide bond
  • Glycoprotein
  • Glycosyltransferase
  • Golgi apparatus
  • Lipid metabolism
  • Reference proteome
  • Secreted
  • Signal-anchor
  • Transmembrane helix
Proteins
Displaying 1 entry
UniProt Protein Name
Q11201
  • Gal-NAc6S
  • Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
  • Monosialoganglioside sialyltransferase
  • SIATFL
  • ST3Gal I
  • ST3GalA.1
  • ST3O
  • Sialyltransferase 4A
Gene Ontology (GO)
GO Hierarchy
Human Protein Atlas
ENSG00000008513

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

GlycoGene Database (GGDB)
GGDB ID
gg048
Gene Symbol
  • ST3GAL1
Reactions
Displaying 1 entry
Donor Acceptor Product Reference
CMP-Neu5Ac
G00031MO
G65562ZE
Displaying all 7 entries
Donor Acceptor Product Reference
CMP-Neu5Ac
G00049MO
CMP-Neu5Ac
G00056MO
CMP-Neu5Ac
G21856LC
CMP-Neu5Ac
G00033MO
G85608AG
CMP-Neu5Ac
G11647UD
G51162XR
CMP-Neu5Ac
G48558GR
G46677TE
CMP-Neu5Ac
G00031MO
G65562ZE
Displaying all 5 entries
Donor Acceptor Product Reference
CMP-Neu5Ac
G84224TW
CMP-Neu5Ac
G58896AZ
CMP-Neu5Ac
G72002FC
CMP-Neu5Ac
G00055MO
CMP-Neu5Ac
G26123AX
Orthologous Gene
Displaying all 2 entries
Species Protein mRNA
Rattus norvegicus XP_343255 XM_343255
Mus musculus NP_033203 NM_009177
KEGG BRITE Database
Orthology
K00780
Name
beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4A) [EC:2.4.3.2 2.4.3.4]
References
Reactions
Disease
Disease Ontology
Displaying entries 1 - 10 of 26 in total
DO ID Disease Name Source
DOID:0111391 mucopolysaccharidosis IVA
DOID:10283 prostate cancer
DOID:10286 prostate carcinoma
DOID:11054 urinary bladder cancer
DOID:11328 schizophreniform disorder
DOID:12361 Graves' disease
DOID:12804 mucopolysaccharidosis IV
DOID:1612 breast cancer
DOID:162 cancer
DOID:2394 ovarian cancer
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP000994
Gene Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 1

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024