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YTH N6-methyladenosine RNA binding protein C2

Summary

Gene Symbol

YTHDC2

Organism

Homo sapiens (human)

External Links

NCBI Gene

64848

PubChem

64848

Alliance of Genome Resources

HGNC:24721

JoGo

YTHDC2

TogoVar

YTHDC2

Annotation

Keyword

3D-structure
ANK repeat
Cytoplasm
Helicase
Meiosis
Oogenesis
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome
Repeat
Spermatogenesis

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9H6S0	YTH domain-containing protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
spermatid development	ISS
response to tumor necrosis factor	IDA	21559518
positive regulation by host of viral genome replication	IMP	21559518
oocyte development	ISS
meiotic cell cycle	IEA

GO Hierarchy

biological process

cellular process [inference]

cell cycle [inference]

meiotic cell cycle

cell cycle process [inference]

cell cycle switching [inference]

cell cycle switching, mitotic to meiotic cell cycle [inference]

germline cell cycle switching, mitotic to meiotic cell cycle

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

reproductive process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

meiotic cell cycle

developmental process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

anatomical structure development [inference]

cell development [inference]

germ cell development [inference]

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

modulation by host of symbiont process [inference]

modulation by host of viral process [inference]

positive regulation by host of viral process [inference]

positive regulation by host of viral genome replication

modulation by host of viral genome replication [inference]

positive regulation by host of viral genome replication

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of meiotic cell cycle [inference]

cell cycle switching, mitotic to meiotic cell cycle [inference]

germline cell cycle switching, mitotic to meiotic cell cycle

positive regulation of reproductive process [inference]

positive regulation of meiotic cell cycle [inference]

cell cycle switching, mitotic to meiotic cell cycle [inference]

germline cell cycle switching, mitotic to meiotic cell cycle

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

cell cycle switching, mitotic to meiotic cell cycle [inference]

germline cell cycle switching, mitotic to meiotic cell cycle

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of meiotic cell cycle [inference]

cell cycle switching, mitotic to meiotic cell cycle [inference]

germline cell cycle switching, mitotic to meiotic cell cycle

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

cell cycle switching, mitotic to meiotic cell cycle [inference]

germline cell cycle switching, mitotic to meiotic cell cycle

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

cell cycle switching, mitotic to meiotic cell cycle [inference]

germline cell cycle switching, mitotic to meiotic cell cycle

negative regulation of cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

cell cycle switching, mitotic to meiotic cell cycle [inference]

germline cell cycle switching, mitotic to meiotic cell cycle

positive regulation of cell cycle [inference]

positive regulation of meiotic cell cycle [inference]

cell cycle switching, mitotic to meiotic cell cycle [inference]

germline cell cycle switching, mitotic to meiotic cell cycle

regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle [inference]

cell cycle switching, mitotic to meiotic cell cycle [inference]

germline cell cycle switching, mitotic to meiotic cell cycle

regulation of reproductive process [inference]

regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle [inference]

cell cycle switching, mitotic to meiotic cell cycle [inference]

germline cell cycle switching, mitotic to meiotic cell cycle

positive regulation of reproductive process [inference]

positive regulation of meiotic cell cycle [inference]

cell cycle switching, mitotic to meiotic cell cycle [inference]

germline cell cycle switching, mitotic to meiotic cell cycle

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	21559518
ribonucleoprotein granule	ISS
perinuclear region of cytoplasm	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribonucleoprotein granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

ribonucleoprotein granule

perinuclear region of cytoplasm

supramolecular complex [inference]

ribonucleoprotein granule

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
RNA binding	IBA
RNA binding	HDA	22658674 22681889
helicase activity	IBA
protein binding	IPI	21903422 26742488 29033321
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity

RNA helicase activity [inference]

3'-5' RNA helicase activity

catalytic activity, acting on RNA [inference]

RNA helicase activity [inference]

3'-5' RNA helicase activity

binding [inference]

protein binding

enzyme binding [inference]

RNA polymerase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

protein-RNA adaptor activity [inference]

N6-methyladenosine-containing RNA reader activity

ATP-dependent activity [inference]

helicase activity

RNA helicase activity [inference]

3'-5' RNA helicase activity

ATP-dependent activity, acting on RNA

RNA helicase activity [inference]

3'-5' RNA helicase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ATP-dependent RNA helicase

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
ATP binding

Displaying **all 4** entries
InterPro
DEAD-box helicase, OB fold
Helicase associated domain (HA2), winged-helix domain
Helicase-associated domain
P-loop containing nucleoside triphosphate hydrolase