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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
SIX homeobox 1
Summary
- Gene Symbol
-
- SIX1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Activator
- Apoptosis
- Cytoplasm
- DNA-binding
- Developmental protein
- Disease variant
- Homeobox
- Non-syndromic deafness
- Nucleus
- Phosphoprotein
- Reference proteome
- Repressor
- Transcription regulation
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| Q15475 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| neuron fate specification | ||
| sensory perception of sound | ||
| positive regulation of secondary heart field cardioblast proliferation | ||
| regulation of neuron differentiation | ||
| regulation of synaptic assembly at neuromuscular junction |
GO Hierarchy
biological process
cellular process [inference]
developmental process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of developmental process [inference]
regulation of anatomical structure morphogenesis [inference]
regulation of cell differentiation [inference]
positive regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
regulation of cell population proliferation [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | ||
| DNA binding | ||
| chromatin binding | ||
| sequence-specific double-stranded DNA binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Homeobox protein
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| InterPro |
|---|
| Homeobox domain |
| Homeobox protein SIX1, N-terminal SD domain |
| Homeobox, conserved site |
| Homeobox-like domain superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110553 | autosomal dominant nonsyndromic deafness 23 | |
| DOID:14702 | branchiootorenal syndrome | |
| DOID:1612 | breast cancer | |
| DOID:2154 | nephroblastoma | |
| DOID:3192 | neurilemmoma | |
| DOID:4001 | ovarian carcinoma | |
| DOID:684 | hepatocellular carcinoma |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 20471 | MGI:102780 | MOUSE08959 | ||
| 35662 | FB:FBgn0003460 | |||
| 114634 | RGD:620906 | RATNO36471 | ||
| 178919 | WB:WBGene00000455 | |||
| 191622 | WB:WBGene00000454 | |||
| 398185 | Xenbase:XB-GENE-480721 | |||
| 404627 | ZFIN:ZDB-GENE-040426-2308 | |||
| 452952 | 9598_0:003b76 | PANTR08890 | ||
| 490719 | CANLF17969 | |||
| 494168 | ZFIN:ZDB-GENE-040718-155 |
