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5-hydroxytryptamine receptor 7

Summary

Gene Symbol

Htr7

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

65032

PubChem

65032

Alliance of Genome Resources

RGD:71034

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P32305	5-HT-X GPRFO Serotonin receptor 7
A6I144	Serotonin receptor 7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 20 in total

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GO Term	Evidence Code	PMID
presynaptic modulation of chemical synaptic transmission	EXP IDA	26779891
regulation of vein smooth muscle contraction	IMP	31125290
smooth muscle contraction	IEA
adenylate cyclase-activating serotonin receptor signaling pathway	IDA IEA ISO	8394362
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA TAS	8397408

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

serotonin receptor signaling pathway

adenylate cyclase-activating serotonin receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

dopaminergic neuron differentiation

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction

urinary tract smooth muscle contraction [inference]

urinary bladder smooth muscle contraction

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

regulation of vascular associated smooth muscle contraction [inference]

regulation of vein smooth muscle contraction

vasoconstriction

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory

behavior [inference]

learning or memory [inference]

memory

behavioral response to pain

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

dopaminergic neuron differentiation

rhythmic process [inference]

circadian rhythm

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to abiotic stimulus [inference]

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to electrical stimulus

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to alcohol [inference]

response to corticosterone

response to ketone [inference]

response to corticosterone

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to corticosterone

response to ketone [inference]

response to corticosterone

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception of pain [inference]

detection of mechanical stimulus involved in sensory perception of pain

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

presynaptic modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of serotonin secretion [inference]

negative regulation of serotonin secretion

negative regulation of monoatomic ion transport [inference]

negative regulation of serotonin secretion

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

regulation of secretion by cell [inference]

regulation of serotonin secretion [inference]

negative regulation of serotonin secretion

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

negative regulation of transport [inference]

negative regulation of monoatomic ion transport [inference]

negative regulation of serotonin secretion

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

negative regulation of transport [inference]

negative regulation of monoatomic ion transport [inference]

negative regulation of serotonin secretion

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

serotonin receptor signaling pathway

adenylate cyclase-activating serotonin receptor signaling pathway

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

presynaptic modulation of chemical synaptic transmission

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of secretion by cell [inference]

regulation of serotonin secretion [inference]

negative regulation of serotonin secretion

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of smooth muscle contraction [inference]

regulation of vascular associated smooth muscle contraction [inference]

regulation of vein smooth muscle contraction

regulation of blood circulation [inference]

regulation of vasoconstriction [inference]

regulation of vascular associated smooth muscle contraction [inference]

regulation of vein smooth muscle contraction

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

regulation of vascular associated smooth muscle contraction [inference]

regulation of vein smooth muscle contraction

vasoconstriction

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
presynaptic membrane	IDA	16082681
synapse	IEA
synaptic vesicle	IDA	16082681

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus

presynapse [inference]

axon terminus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
neurotransmitter receptor activity	IBA IDA	8394362
G protein-coupled serotonin receptor activity	IBA IDA IEA ISO	8394362

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled serotonin receptor activity

neurotransmitter receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

5-Hydroxytryptamine 7 receptor

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
G protein-coupled serotonin receptor signaling pathway
chemical synaptic transmission
neurotransmitter receptor activity
smooth muscle contraction

Displaying **all 3** entries
InterPro
5-Hydroxytryptamine 7 receptor
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
neuronal cell body	PMID:16082681
axon terminus	PMID:16082681
dendrite	PMID:16082681
synaptic vesicle	PMID:16082681

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:10914	amnestic disorder	Alliance of Genome Resources
DOID:1561	cognitive disorder	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:1825	childhood absence epilepsy	Alliance of Genome Resources
DOID:2030	anxiety disorder	Alliance of Genome Resources
DOID:6364	migraine	Alliance of Genome Resources
DOID:9778	irritable bowel syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of **103** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Mesocricetus auratus	101842111	10036_0:000640
Melopsittacus undulatus	101877882		MELUD14006
Ictidomys tridecemlineatus	101968941	43179_0:003be8	ICTTR16191
Microtus ochrogaster	101984563	79684_0:0017f0
Chinchilla lanigera	102012876	34839_0:001876	CHILA07864
Macaca fascicularis	102118538		MACFA42977
Capra hircus	102181834		CAPHI17989
Latimeria chalumnae	102349426		LATCH01192
Pelodiscus sinensis	102453501		PELSI10589
Peromyscus maniculatus bairdii	102918305	230844_0:000657

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements