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cyclin dependent kinase 15

Summary

Gene Symbol

CDK15

Organism

Homo sapiens (human)

External Links

NCBI Gene

65061

PubChem

65061

Alliance of Genome Resources

HGNC:14434

Annotation

Keyword

ATP-binding
Alternative splicing
Magnesium
Metal-binding
Reference proteome
Serine/threonine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96Q40	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein Cell division protein kinase 15 Serine/threonine-protein kinase ALS2CR7 Serine/threonine-protein kinase PFTAIRE-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein phosphorylation	IEA
regulation of cell cycle phase transition	IBA
regulation of cell cycle	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cell cycle

regulation of cell cycle process [inference]

regulation of cell cycle phase transition

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	IBA
cytosol	IBA
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

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GO Term	Evidence Code	PMID
protein binding	IPI	22939624 23602568 25036637 33961781
protein serine kinase activity	IEA
cyclin binding	IBA
metal ion binding	IEA
protein serine/threonine kinase activity	IDA	24866247

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein kinase activity [inference]

cyclin-dependent protein serine/threonine kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein kinase activity [inference]

cyclin-dependent protein serine/threonine kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein kinase activity [inference]

cyclin-dependent protein serine/threonine kinase activity

protein serine kinase activity

binding [inference]

protein binding

cyclin binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cyclin

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
kinase activity
nucleotide binding
phosphorylation
transferase activity

Displaying **all 4** entries
InterPro
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Serine/threonine-protein kinase, active site

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050453	lissencephaly	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 66 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	38433		FB:FBgn0005640
Caenorhabditis elegans	171672		WB:WBGene00022519
Mus musculus	271697		MGI:3583944	MOUSE28866
Rattus norvegicus	301440		RGD:1306205	RATNO42982
Pan troglodytes	459880	9598_0:000d3a		PANTR29535
Canis lupus familiaris	478873			CANLF14126
Macaca mulatta	703719			MACMU06404
Xenopus tropicalis	780381		Xenbase:XB-GENE-961241
Danio rerio	791619		ZFIN:ZDB-GENE-060421-7193	DANRE38276
Saccharomyces cerevisiae S288C	856076		SGD:S000005952

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OrthoDB (Group)

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Acknowledgements