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solute carrier family 1 member 4

Summary

Gene Symbol

SLC1A4

Organism

Homo sapiens (human)

External Links

NCBI Gene

6509

PubChem

6509

Alliance of Genome Resources

HGNC:10942

JoGo

SLC1A4

TogoVar

SLC1A4

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Amino-acid transport
Antiport
Cell membrane
Disease variant
Epilepsy
Glycoprotein
Intellectual disability
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Sodium
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P43007	Alanine/serine/cysteine/threonine transporter 1 Solute carrier family 1 member 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
amino acid transport	TAS
glutamine transport	TAS	21757002
L-alanine transport	IDA	8101838 8340364 8910405
L-cystine transport	IDA	8101838 8340364 8910405
L-glutamate transmembrane transport	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

proline transmembrane transport

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

nervous system process [inference]

cognition

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

vascular transport [inference]

transport across blood-brain barrier

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

proline transmembrane transport

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

amino acid transport

sulfur amino acid transport [inference]

L-cystine transport

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

proline transmembrane transport

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

neutral amino acid transport [inference]

alanine transport [inference]

L-alanine transport

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

serine transport [inference]

L-serine transport

L-serine import across plasma membrane

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-amino acid transport [inference]

L-alanine transport

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

L-cystine transport

L-serine transport

L-serine import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

hydroxyproline transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

proline transmembrane transport

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

amino acid transport

sulfur amino acid transport [inference]

L-cystine transport

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

proline transmembrane transport

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

neutral amino acid transport [inference]

alanine transport [inference]

L-alanine transport

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

serine transport [inference]

L-serine transport

L-serine import across plasma membrane

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-amino acid transport [inference]

L-alanine transport

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

L-cystine transport

L-serine transport

L-serine import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

hydroxyproline transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

proline transmembrane transport

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

proline transmembrane transport

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

modified amino acid transport [inference]

nitrogen compound transport [inference]

amino acid transport

sulfur amino acid transport [inference]

L-cystine transport

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

proline transmembrane transport

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

neutral amino acid transport [inference]

alanine transport [inference]

L-alanine transport

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

serine transport [inference]

L-serine transport

L-serine import across plasma membrane

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-amino acid transport [inference]

L-alanine transport

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

L-cystine transport

L-serine transport

L-serine import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

hydroxyproline transport

amide transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

modified amino acid transport [inference]

sulfur compound transport [inference]

sulfur amino acid transport [inference]

L-cystine transport

import into cell [inference]

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
centrosome	IDA
intermediate filament	ISS
plasma membrane	TAS
plasma membrane	IC	8910405
plasma membrane	IMP	26041762

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

cell surface

membrane

plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

cell body [inference]

neuronal cell body

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
chloride channel activity	IDA	8910405
amino acid transmembrane transporter activity	TAS
L-alanine transmembrane transporter activity	IDA	8101838 8340364 8910405
L-alanine transmembrane transporter activity	IMP	26041762
L-alanine transmembrane transporter activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

monocarboxylic acid transmembrane transporter activity [inference]

L-hydroxyproline transmembrane transporter activity

amino acid transmembrane transporter activity

sulfur amino acid transmembrane transporter activity [inference]

L-cystine transmembrane transporter activity

acidic amino acid transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity [inference]

alanine transmembrane transporter activity [inference]

L-alanine transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

C4-dicarboxylate transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

monocarboxylic acid transmembrane transporter activity [inference]

L-hydroxyproline transmembrane transporter activity

amino acid transmembrane transporter activity

sulfur amino acid transmembrane transporter activity [inference]

L-cystine transmembrane transporter activity

acidic amino acid transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity [inference]

alanine transmembrane transporter activity [inference]

L-alanine transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

C4-dicarboxylate transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity

modified amino acid transmembrane transporter activity [inference]

sulfur compound transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

L-cystine transmembrane transporter activity

salt transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Amino acid transporter

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
L-alpha-amino acid transmembrane transport
L-glutamate transmembrane transporter activity
neutral L-amino acid transmembrane transporter activity
symporter activity

Displaying **all 3** entries
InterPro
Sodium
Sodium
Sodium

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070537	spastic tetraplegia, thin corpus callosum, and progressive microcephaly	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements