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solute carrier family 1 member 4

Summary

Gene Symbol

SLC1A4

Organism

Homo sapiens (human)

External Links

NCBI Gene

6509

PubChem

6509

Alliance of Genome Resources

HGNC:10942

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Disease variant
Epilepsy
Glycoprotein
Intellectual disability
Phosphoprotein
Reference proteome
Symport
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P43007	Alanine/serine/cysteine/threonine transporter 1 Solute carrier family 1 member 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
L-alanine transport	IDA	8101838 8340364 8910405
proline transmembrane transport	IEA
L-glutamate transmembrane transport	IBA
threonine transport	IDA	8340364
L-cystine transport	IDA	8101838 8340364 8910405

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

proline transmembrane transport

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

nervous system process [inference]

cognition

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

vascular transport [inference]

transport across blood-brain barrier

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

proline transmembrane transport

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

amino acid transport

sulfur amino acid transport [inference]

L-cystine transport

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

proline transmembrane transport

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

neutral amino acid transport [inference]

alanine transport [inference]

L-alanine transport

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

serine transport [inference]

L-serine transport

L-serine import across plasma membrane

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-amino acid transport [inference]

L-alanine transport

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

L-cystine transport

L-serine transport

L-serine import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

hydroxyproline transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

proline transmembrane transport

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

amino acid transport

sulfur amino acid transport [inference]

L-cystine transport

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

proline transmembrane transport

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

neutral amino acid transport [inference]

alanine transport [inference]

L-alanine transport

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

serine transport [inference]

L-serine transport

L-serine import across plasma membrane

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-amino acid transport [inference]

L-alanine transport

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

L-cystine transport

L-serine transport

L-serine import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

hydroxyproline transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

proline transmembrane transport

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

proline transmembrane transport

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

modified amino acid transport [inference]

nitrogen compound transport [inference]

amino acid transport

sulfur amino acid transport [inference]

L-cystine transport

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

proline transmembrane transport

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

neutral amino acid transport [inference]

alanine transport [inference]

L-alanine transport

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

serine transport [inference]

L-serine transport

L-serine import across plasma membrane

serine import across plasma membrane [inference]

L-serine import across plasma membrane

L-amino acid transport [inference]

L-alanine transport

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

L-cystine transport

L-serine transport

L-serine import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-serine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

hydroxyproline transport

amide transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

modified amino acid transport [inference]

sulfur compound transport [inference]

sulfur amino acid transport [inference]

L-cystine transport

import into cell [inference]

amino acid import across plasma membrane [inference]

serine import across plasma membrane [inference]

L-serine import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
membrane	HDA IDA NAS	19946888 26041762 8101838
plasma membrane	IBA IC IMP TAS	26041762 8910405
cell surface	HDA	19581412
melanosome	IEA
intermediate filament	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

cell surface

membrane

plasma membrane

cell junction [inference]

synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
L-threonine transmembrane transporter activity	IBA IDA	8340364
symporter activity	IEA
L-serine transmembrane transporter activity	IBA IDA IMP	26041762 8101838 8340364 8910405
L-hydroxyproline transmembrane transporter activity	IDA	14502423
L-cystine transmembrane transporter activity	IDA	8101838 8340364 8910405

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

monocarboxylic acid transmembrane transporter activity [inference]

L-hydroxyproline transmembrane transporter activity

amino acid transmembrane transporter activity

sulfur amino acid transmembrane transporter activity [inference]

L-cystine transmembrane transporter activity

acidic amino acid transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity [inference]

alanine transmembrane transporter activity [inference]

L-alanine transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

C4-dicarboxylate transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

monocarboxylic acid transmembrane transporter activity [inference]

L-hydroxyproline transmembrane transporter activity

amino acid transmembrane transporter activity

sulfur amino acid transmembrane transporter activity [inference]

L-cystine transmembrane transporter activity

acidic amino acid transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity [inference]

alanine transmembrane transporter activity [inference]

L-alanine transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

C4-dicarboxylate transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity

modified amino acid transmembrane transporter activity [inference]

sulfur compound transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

L-cystine transmembrane transporter activity

salt transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

amino acid transporter

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
L-alpha-amino acid transmembrane transport
L-glutamate transmembrane transporter activity
neutral L-amino acid transmembrane transporter activity
symporter activity

Displaying **all 3** entries
InterPro
Sodium
Sodium
Sodium

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0050994	episodic ataxia type 6	Alliance of Genome Resources
DOID:0070537	spastic tetraplegia, thin corpus callosum, and progressive microcephaly	Alliance of Genome Resources
DOID:1289	neurodegenerative disease	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	34251		FB:FBgn0026439
Mus musculus	55963		MGI:2135601	MOUSE07372
Caenorhabditis elegans	188744		WB:WBGene00001622
Rattus norvegicus	305540		RGD:735146	RATNO08571
Bos taurus	326577			BOVIN02653
Danio rerio	368885		ZFIN:ZDB-GENE-030616-566	DANRE05950
Sus scrofa	396600			PIGXX21937
Pan troglodytes	459278	9598_0:000bca		PANTR27749
Canis lupus familiaris	481391			CANLF01887
Macaca mulatta	699288			MACMU07277

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements