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solute carrier family 1 member 6

Summary

Gene Symbol

SLC1A6

Organism

Homo sapiens (human)

External Links

NCBI Gene

6511

PubChem

6511

Alliance of Genome Resources

HGNC:10944

Annotation

Keyword

Alternative splicing
Amino-acid transport
Cell membrane
Chloride
Glycoprotein
Metal-binding
Phosphoprotein
Potassium
Reference proteome
Sodium
Symport
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P48664	Sodium-dependent glutamate/aspartate transporter Solute carrier family 1 member 6
B7Z7Q5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
establishment of localization in cell	IEA
neurotransmitter uptake	IDA IMP NAS	7791878
L-glutamate transmembrane transport	IBA
neutral amino acid transport	IEA
L-glutamate import across plasma membrane	IDA ISS	7791878

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

neurotransmitter transport

neurotransmitter uptake

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

neutral amino acid transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

neutral amino acid transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

nitrogen compound transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

neutral amino acid transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amide transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

import into cell [inference]

neurotransmitter uptake

amino acid import across plasma membrane [inference]

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of biological quality [inference]

regulation of membrane potential

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
intermediate filament cytoskeleton	IDA
membrane	TAS	7791878
Golgi apparatus	IEA
plasma membrane	IBA IDA ISS TAS
membrane protein complex	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
glutamate:sodium symporter activity	IBA IDA	7791878
metal ion binding	IEA
L-glutamate transmembrane transporter activity	IBA IDA	7791878
L-aspartate transmembrane transporter activity	IDA	7791878
neutral L-amino acid transmembrane transporter activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

amino acid transmembrane transporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

acidic amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

L-aspartate transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

L-aspartate transmembrane transporter activity

C4-dicarboxylate transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

amino acid transmembrane transporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

acidic amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

L-aspartate transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

L-aspartate transmembrane transporter activity

C4-dicarboxylate transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

amide transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

salt transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

amino acid transporter

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
L-alpha-amino acid transmembrane transport
L-glutamate transmembrane transporter activity
neutral L-amino acid transmembrane transporter activity
symporter activity

Displaying **all 3** entries
InterPro
Sodium
Sodium
Sodium

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050994	episodic ataxia type 6	Alliance of Genome Resources
DOID:1289	neurodegenerative disease	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	20513		MGI:1096331	MOUSE02540
Drosophila melanogaster	34251		FB:FBgn0026439
Rattus norvegicus	84012		RGD:620340	RATNO37416
Caenorhabditis elegans	188744		WB:WBGene00001622
Canis lupus familiaris	403749			CANLF07732
Pan troglodytes	455789	9598_0:004a09		PANTR17446
Bos taurus	538673			BOVIN32362
Danio rerio	559270		ZFIN:ZDB-GENE-071004-45
Macaca mulatta	719023			MACMU20309
Monodelphis domestica	100012047			MONDO19176

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements