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solute carrier family 2 member 1

Summary

Gene Symbol

SLC2A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6513

PubChem

6513

Alliance of Genome Resources

HGNC:11005

Annotation

Keyword

3D-structure
Acetylation
Cataract
Cell membrane
Direct protein sequencing
Disease variant
Dystonia
Epilepsy
Glycoprotein
Hereditary hemolytic anemia
Intellectual disability
Phosphoprotein
Reference proteome
Sugar transport
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q59GX2	Glucose transporter type 1, erythrocyte/brain
P11166	Glucose transporter type 1, erythrocyte/brain HepG2 glucose transporter

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 25 in total

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GO Term	Evidence Code	PMID
L-ascorbic acid metabolic process	TAS
cerebral cortex development	IEA
response to insulin	IBA
cellular response to glucose starvation	IEA
xenobiotic transport	IEA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

heterocycle metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

L-ascorbic acid metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

organic cyclic compound metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

heterocycle metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to osmotic stress [inference]

cellular hyperosmotic response

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

fucose transmembrane transport

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

import across plasma membrane [inference]

long-chain fatty acid import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

multi-multicellular organism process [inference]

female pregnancy

photoreceptor cell maintenance

developmental process [inference]

anatomical structure development [inference]

cerebral cortex development

system development [inference]

central nervous system development

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to osmotic stress [inference]

hyperosmotic response [inference]

cellular hyperosmotic response

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to external stimulus [inference]

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to mechanical stimulus

response to abiotic stimulus [inference]

response to osmotic stress [inference]

hyperosmotic response [inference]

cellular hyperosmotic response

cellular response to osmotic stress [inference]

cellular hyperosmotic response

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to osmotic stress [inference]

cellular hyperosmotic response

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to Thyroglobulin triiodothyronine

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to osmotic stress [inference]

cellular hyperosmotic response

localization [inference]

establishment of localization [inference]

transport [inference]

vascular transport [inference]

transport across blood-brain barrier

xenobiotic transport

vitamin transport [inference]

dehydroascorbic acid transport

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

fucose transmembrane transport

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

import across plasma membrane [inference]

long-chain fatty acid import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

organic substance transport [inference]

lipid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

lipid import into cell [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

carbohydrate transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

fucose transmembrane transport

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

dehydroascorbic acid transport

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

import into cell [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
female germ cell nucleus	IEA
photoreceptor inner segment	IEA
female pronucleus	IEA
cytosol	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

transporter complex [inference]

glucose transporter complex

cellular anatomical entity [inference]

membrane

plasma membrane

sarcolemma

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

Z disc

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

cell-cell contact zone [inference]

intercalated disc

midbody

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus [inference]

germ cell nucleus [inference]

female germ cell nucleus

pronucleus [inference]

female pronucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus [inference]

germ cell nucleus [inference]

female germ cell nucleus

pronucleus [inference]

female pronucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
long-chain fatty acid transporter activity	IMP	10227690
glucose transmembrane transporter activity
protein binding	IPI	18347014 23563491 25910212 25957687 35810171
fucose transmembrane transporter activity	IEA
kinase binding	IEA

GO Hierarchy

molecular function

transporter activity [inference]

lipid transporter activity [inference]

long-chain fatty acid transporter activity

transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

dehydroascorbic acid transmembrane transporter activity

carbohydrate transmembrane transporter activity [inference]

sugar transmembrane transporter activity [inference]

monosaccharide transmembrane transporter activity [inference]

hexose transmembrane transporter activity [inference]

glucose transmembrane transporter activity

D-glucose transmembrane transporter activity

fucose transmembrane transporter activity

xenobiotic transmembrane transporter activity

vitamin transmembrane transporter activity [inference]

dehydroascorbic acid transmembrane transporter activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

solute carrier family 2

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
InterPro
Glucose transporter GLUT
MFS transporter superfamily
Major facilitator superfamily domain
Major facilitator, sugar transporter-like
Sugar transporter, conserved site
Sugar/inositol transporter

Disease

Disease Ontology

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:0060326	myelomeningocele	Alliance of Genome Resources
DOID:0070560	glucose transporter type 1 deficiency syndrome	Alliance of Genome Resources
DOID:0070561	glucose transporter type 1 deficiency syndrome 1	Alliance of Genome Resources
DOID:0090044	dystonia 9	Alliance of Genome Resources
DOID:0090045	glucose transporter type 1 deficiency syndrome 2	Alliance of Genome Resources
DOID:0111313	obsolete idiopathic generalized epilepsy 12	Alliance of Genome Resources
DOID:1825	childhood absence epilepsy	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of **117** in total

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Species	Gene ID	Orthologous MAtrix
Loxodonta africana	100677089	LOXAF09260
Cavia porcellus	100715554	CAVPO23339
Cricetulus griseus	100753506	CRIGR10340
Sarcophilus harrisii	100915589	SARHA05251
Otolemur garnettii	100959166	OTOGA04242
Pan paniscus	100991584	PANPA01132
Saimiri boliviensis boliviensis	101049410	SAIBB27679
Takifugu rubripes	101073552	TAKRU21279
Gorilla gorilla gorilla	101145851	GORGO18024
Oryzias latipes	101159343	ORYLA14037

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements