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solute carrier family 5 member 1

Summary

Gene Symbol

SLC5A1

Aliases

D22S675
NAGT
SGLT-1
sodium/glucose cotransporter 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6523

HGNC

11036

KEGG Gene ID

hsa:6523

PubChem

6523

Alliance of Genome Resources

HGNC:11036

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disease variant
Disulfide bond
Glycoprotein
Phosphoprotein
Reference proteome
Sodium transport
Sugar transport
Symport
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P13866	High affinity sodium-glucose cotransporter Solute carrier family 5 member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
intestinal D-glucose absorption	ISS
glucose transmembrane transport	IDA IMP	8563765 8836035
galactose transmembrane transport	ISS
pentose transmembrane transport	ISS
transport across blood-brain barrier	IGI NAS	23975336 26590417 30280653

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

pentose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

renal system process [inference]

renal absorption [inference]

renal glucose absorption

digestive system process [inference]

intestinal absorption [inference]

intestinal hexose absorption

intestinal D-glucose absorption

response to stimulus [inference]

response to chemical [inference]

response to inorganic substance

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

vascular transport [inference]

transport across blood-brain barrier

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

fluid transport [inference]

water transport [inference]

transepithelial water transport

epithelial fluid transport [inference]

transepithelial water transport

intestinal absorption [inference]

intestinal hexose absorption

intestinal D-glucose absorption

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

pentose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

transepithelial transport [inference]

epithelial fluid transport [inference]

transepithelial water transport

organic substance transport [inference]

water transport [inference]

transepithelial water transport

carbohydrate transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

pentose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

intestinal hexose absorption

intestinal D-glucose absorption

organic hydroxy compound transport [inference]

myo-inositol transport

carbohydrate derivative transport [inference]

glycoside transport [inference]

glucoside transport [inference]

alpha-glucoside transport

import into cell [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

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GO Term	Evidence Code	PMID
intracellular vesicle		14986005
intracellular organelle	ISS
plasma membrane	IBA IDA TAS	26945065
brush border membrane	ISS
apical plasma membrane	IDA ISS	12773314

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle

intracellular membrane-bounded organelle [inference]

intracellular vesicle

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
galactose:sodium symporter activity	IDA	34880492 35077764
galactose transmembrane transporter activity	ISS
glucose transmembrane transporter activity	IDA	26945065
pentose transmembrane transporter activity	ISS
glucose:sodium symporter activity	IBA IDA TAS	20980548 34880492 35077764 8563765 8836035

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

carbohydrate transmembrane transporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

sugar transmembrane transporter activity [inference]

monosaccharide transmembrane transporter activity [inference]

pentose transmembrane transporter activity

hexose transmembrane transporter activity [inference]

galactose transmembrane transporter activity

galactose:sodium symporter activity

glucose transmembrane transporter activity

fucose transmembrane transporter activity

inorganic molecular entity transmembrane transporter activity [inference]

water transmembrane transporter activity

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

carbohydrate derivative transmembrane transporter activity [inference]

glucoside transmembrane transporter activity [inference]

alpha-glucoside transmembrane transporter activity

organic hydroxy compound transmembrane transporter activity [inference]

polyol transmembrane transporter activity [inference]

myo-inositol transmembrane transporter activity [inference]

myo-inositol:sodium symporter activity

salt transmembrane transporter activity [inference]

water transmembrane transporter activity

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000100170

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K14158

Name

solute carrier family 5 (sodium/glucose cotransporter), member 1

References

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0060763	X-linked juvenile retinoschisis 1	DisGeNET
DOID:0014667	disease of metabolism	DisGeNET
DOID:0040085	bacterial sepsis	DisGeNET
DOID:0050700	cardiomyopathy	DisGeNET DisGeNET DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET DisGeNET
DOID:0080326	familial hypertrophic cardiomyopathy	DisGeNET
DOID:0110425	dilated cardiomyopathy 1A	DisGeNET
DOID:0110741	type 1 diabetes mellitus 2	DisGeNET
DOID:0110742	type 1 diabetes mellitus 3	DisGeNET
DOID:0110743	type 1 diabetes mellitus 4	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 21 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000083	Renal insufficiency
HP:0000787	Nephrolithiasis
HP:0000790	Hematuria
HP:0001508	Failure to thrive
HP:0001824	Weight loss
HP:0001942	Metabolic acidosis
HP:0001944	Dehydration
HP:0001945	Fever
HP:0001986	Hypertonic dehydration

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:606824	glucose-galactose malabsorption
ORPHA:35710	glucose-galactose malabsorption

PubChem Disease

GHR Health Conditions

Glucose-galactose malabsorption

MedGen Diseases

Congenital glucose-galactose malabsorption

OMIM Phenotypes

GLUCOSE/GALACTOSE MALABSORPTION; GGM

KEGG Diseases

Congenital glucose-galactose malabsorption

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **11 - 20** of 75 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Oryzias latipes	101175417		ORYLA02713
Oreochromis niloticus	100699559		ORENI64797
Sparus aurata	115592135		SPAAU35060
Xenopus tropicalis	100498135	Xenbase:XB-GENE-855699
Crocodylus porosus	109312844		CROPO19031
Meleagris gallopavo	723986		MELGA04965
Serinus canaria	103818017		SERCA12753
Sarcophilus harrisii	100922027		SARHA09866
Callithrix jacchus	100402782		CALJA20647
Cercocebus atys	105575764		CERAT19138

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements