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solute carrier family 5 member 2

Summary

Gene Symbol

SLC5A2

Organism

Homo sapiens (human)

External Links

NCBI Gene

6524

PubChem

6524

Alliance of Genome Resources

HGNC:11037

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disease variant
Glycoprotein
Reference proteome
Sodium transport
Sugar transport
Symport
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8WY15
P31639	Low affinity sodium-glucose cotransporter Solute carrier family 5 member 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
sodium ion transport	IBA
sodium ion import across plasma membrane	IDA	20980548
alpha-glucoside transport	IDA	20980548 26376857
glucose import across plasma membrane	IDA	20980548
renal glucose absorption	ISS

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

cellular process [inference]

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal absorption [inference]

renal glucose absorption

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

organic substance transport [inference]

carbohydrate transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

carbohydrate derivative transport [inference]

glycoside transport [inference]

glucoside transport [inference]

alpha-glucoside transport

import into cell [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
membrane	TAS	8244402
apical plasma membrane	ISS
plasma membrane	IBA IDA TAS	26376857
extracellular exosome	HDA	19056867

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	28514442 33961781 34880493 38057552
alpha-glucoside transmembrane transporter activity	IDA	20980548 26376857
low-affinity glucose:sodium symporter activity	TAS	8244402
glucose:sodium symporter activity	EXP IBA IDA TAS	11133510 20980548 28592437
D-glucose transmembrane transporter activity	IDA	20980548

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

glucose:sodium symporter activity

low-affinity glucose:sodium symporter activity

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

low-affinity glucose:sodium symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

low-affinity glucose:sodium symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

glucose:sodium symporter activity

low-affinity glucose:sodium symporter activity

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

low-affinity glucose:sodium symporter activity

carbohydrate transmembrane transporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

glucose:sodium symporter activity

low-affinity glucose:sodium symporter activity

sugar transmembrane transporter activity [inference]

monosaccharide transmembrane transporter activity [inference]

hexose transmembrane transporter activity [inference]

glucose transmembrane transporter activity [inference]

glucose:sodium symporter activity

low-affinity glucose:sodium symporter activity

D-glucose transmembrane transporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

low-affinity glucose:sodium symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

glucose:sodium symporter activity

low-affinity glucose:sodium symporter activity

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

low-affinity glucose:sodium symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

glucose:sodium symporter activity

low-affinity glucose:sodium symporter activity

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

low-affinity glucose:sodium symporter activity

carbohydrate derivative transmembrane transporter activity [inference]

glucoside transmembrane transporter activity [inference]

alpha-glucoside transmembrane transporter activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

glucose:sodium symporter activity

low-affinity glucose:sodium symporter activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transporter

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Sodium/glucose symporter superfamily
Sodium/solute symporter

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:10763	hypertension	Alliance of Genome Resources
DOID:9432	renal glycosuria	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 68 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	64522		RGD:620217	RATNO18900
Mus musculus	246787		MGI:2181411	MOUSE54035
Bos taurus	399680			BOVIN20660
Danio rerio	405862		ZFIN:ZDB-GENE-040426-2498	DANRE08416
Xenopus laevis	447523		Xenbase:XB-GENE-5961982
Pan troglodytes	467963	9598_0:0042fb		PANTR12243
Canis lupus familiaris	492301			CANLF16351
Macaca mulatta	714228			MACMU27484
Oryctolagus cuniculus	100009386			RABIT15412
Monodelphis domestica	100016631			MONDO29290