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solute carrier family 7 member 1

Summary

Gene Symbol

SLC7A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6541

PubChem

6541

Alliance of Genome Resources

HGNC:11057

Annotation

Keyword

Amino-acid transport
Cell membrane
Direct protein sequencing
Glycoprotein
Receptor
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P30825	Ecotropic retroviral leukemia receptor homolog Ecotropic retrovirus receptor homolog Solute carrier family 7 member 1 System Y+ basic amino acid transporter

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
amino acid transport	TAS
L-amino acid transport	IDA	28684763
lysine transport	IDA	11891586
ornithine transport	IMP	17197568
positive regulation of T cell proliferation	IMP	26449889

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

azole transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

import across plasma membrane [inference]

amino acid import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

localization [inference]

establishment of localization [inference]

transport [inference]

vascular transport [inference]

transport across blood-brain barrier

transmembrane transport [inference]

azole transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

import across plasma membrane [inference]

amino acid import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

amino acid transport

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

aromatic amino acid transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transport [inference]

lysine transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

L-amino acid transport

L-lysine transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

ornithine transport

L-ornithine transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

organic acid transport [inference]

carboxylic acid transport [inference]

amino acid transport

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

aromatic amino acid transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transport [inference]

lysine transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

L-amino acid transport

L-lysine transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

ornithine transport

L-ornithine transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

azole transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

modified amino acid transport [inference]

nitrogen compound transport [inference]

amino acid transport

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

aromatic amino acid transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transport [inference]

lysine transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

L-amino acid transport

L-lysine transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

ornithine transport

L-ornithine transmembrane transport

azole transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

modified amino acid transport [inference]

import into cell [inference]

amino acid import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
basolateral plasma membrane	IDA	11891586 31791063
apical plasma membrane	ISS
apical plasma membrane	IDA	31791063
protein-containing complex	IDA	28246125

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
L-ornithine transmembrane transporter activity	ISS
L-ornithine transmembrane transporter activity	IBA
virus receptor activity	IEA
L-histidine transmembrane transporter activity	IDA	11591158
protein binding	IPI	25416956 28514442 30956113 32296183

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity

aromatic amino acid transmembrane transporter activity [inference]

L-histidine transmembrane transporter activity

basic amino acid transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity

aromatic amino acid transmembrane transporter activity [inference]

L-histidine transmembrane transporter activity

basic amino acid transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

modified amino acid transmembrane transporter activity [inference]

L-arginine transmembrane transporter activity

azole transmembrane transporter activity [inference]

L-histidine transmembrane transporter activity

salt transmembrane transporter activity [inference]

L-lysine transmembrane transporter activity

binding [inference]

protein binding

exogenous protein binding [inference]

virus receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cationic amino acid transporter

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Amino acid/polyamine transporter I
Cationic amino acid transporter, C-terminal

Ortholog

Displaying entries **1 - 10** of 92 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6541	Xenbase:XB-GENE-984439
Saccharomyces cerevisiae S288C	6542	SGD:S000001839
Saccharomyces cerevisiae S288C	6545	SGD:S000001839
Mus musculus	11987	Xenbase:XB-GENE-984439	MOUSE44357
Saccharomyces cerevisiae S288C	11988	SGD:S000001839
Saccharomyces cerevisiae S288C	11989	SGD:S000001839
Rattus norvegicus	25648		RATNO06153
Saccharomyces cerevisiae S288C	29485	SGD:S000001839
Saccharomyces cerevisiae S288C	57709	SGD:S000001839
Saccharomyces cerevisiae S288C	64554	SGD:S000001839

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements