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solute carrier family 7 member 1

Summary

Gene Symbol

SLC7A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6541

PubChem

6541

Alliance of Genome Resources

HGNC:11057

Annotation

Keyword

Amino-acid transport
Cell membrane
Direct protein sequencing
Glycoprotein
Receptor
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P30825	Ecotropic retroviral leukemia receptor homolog Ecotropic retrovirus receptor homolog Solute carrier family 7 member 1 System Y+ basic amino acid transporter

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
amino acid transport	TAS
L-amino acid transport	IDA	28684763
lysine transport	IDA	11891586
ornithine transport	IMP	17197568
positive regulation of T cell proliferation	IMP	26449889

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

azole transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

import across plasma membrane [inference]

amino acid import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

localization [inference]

establishment of localization [inference]

transport [inference]

vascular transport [inference]

transport across blood-brain barrier

transmembrane transport [inference]

azole transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

import across plasma membrane [inference]

amino acid import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

amino acid transport

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

aromatic amino acid transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transport [inference]

lysine transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

L-amino acid transport

L-lysine transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

ornithine transport

L-ornithine transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

organic acid transport [inference]

carboxylic acid transport [inference]

amino acid transport

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

aromatic amino acid transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transport [inference]

lysine transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

L-amino acid transport

L-lysine transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

ornithine transport

L-ornithine transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

azole transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

modified amino acid transport [inference]

nitrogen compound transport [inference]

amino acid transport

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

aromatic amino acid transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

basic amino acid transport [inference]

lysine transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

L-amino acid transport

L-lysine transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

ornithine transport

L-ornithine transmembrane transport

azole transmembrane transport [inference]

L-histidine transmembrane transport [inference]

L-histidine import across plasma membrane

modified amino acid transport [inference]

import into cell [inference]

amino acid import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	28112518
plasma membrane	IBA
basal plasma membrane	ISS
membrane	HDA	19946888

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
L-ornithine transmembrane transporter activity	ISS
L-ornithine transmembrane transporter activity	IBA
virus receptor activity	IEA
L-histidine transmembrane transporter activity	IDA	11591158
protein binding	IPI	25416956 28514442 30956113 32296183

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity

aromatic amino acid transmembrane transporter activity [inference]

L-histidine transmembrane transporter activity

basic amino acid transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity

aromatic amino acid transmembrane transporter activity [inference]

L-histidine transmembrane transporter activity

basic amino acid transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

modified amino acid transmembrane transporter activity [inference]

L-arginine transmembrane transporter activity

azole transmembrane transporter activity [inference]

L-histidine transmembrane transporter activity

salt transmembrane transporter activity [inference]

L-lysine transmembrane transporter activity

binding [inference]

protein binding

exogenous protein binding [inference]

virus receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cationic amino acid transporter

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Amino acid/polyamine transporter I
Cationic amino acid transporter, C-terminal

Ortholog

Displaying entries **41 - 50** of 92 in total

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Species	Gene ID	Orthologous MAtrix
Saimiri boliviensis boliviensis	101033414	SAIBB00025
Felis catus	101089066	FELCA01575
Tursiops truncatus	101318597	TURTR13712
Octodon degus	101575810	OCTDE08142
Jaculus jaculus	101603984	JACJA11508
Mustela putorius furo	101682675	MUSPF03856
Heterocephalus glaber	101708236	HETGA04404
Anas platyrhynchos platyrhynchos	101795832	ANAPP05578
Ficedula albicollis	101821956	FICAL05414
Melopsittacus undulatus	101876065	MELUD06721

GlyTouCan

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OrthoDB (Group)

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Acknowledgements