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solute carrier family 12 member 1

Summary

Gene Symbol

SLC12A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6557

PubChem

6557

Alliance of Genome Resources

HGNC:10910

Annotation

Keyword

Alternative splicing
Bartter syndrome
Cell membrane
Chloride
Coiled coil
Disease variant
Glycoprotein
Neurodegeneration
Phosphoprotein
Potassium transport
Proteomics identification
Reference proteome
Sodium transport
Symport
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
B4DPF4
Q13621	Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1 Kidney-specific Na-K-Cl symporter Na-K-2Cl cotransporter 2
Q8IUN5
A0A8I5KSK6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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2

3

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GO Term	Evidence Code	PMID
monoatomic ion transport	TAS
ion transport	TAS
cell volume homeostasis	IDA	21321328
cell volume homeostasis	IBA
ion transmembrane transport	ISS

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

monoatomic anion homeostasis [inference]

chloride ion homeostasis

inorganic ion homeostasis [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

sodium ion transport [inference]

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

biological regulation [inference]

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

Displaying entries **1 - 5** of 7 in total

1

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GO Term	Evidence Code	PMID
plasma membrane	TAS
membrane	TAS	7929272
apical plasma membrane	ISS
apical plasma membrane	IDA	21321328
apical plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
sodium:potassium:chloride symporter activity	TAS
sodium:potassium:chloride symporter activity	IDA	21321328
sodium:potassium:chloride symporter activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

potassium:sodium symporter activity [inference]

sodium:potassium:chloride symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

potassium:chloride symporter activity [inference]

sodium:potassium:chloride symporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

solute carrier family 12 member

Functional Category

E: Amino acid transport and metabolism
K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
cell volume homeostasis
chloride ion homeostasis
chloride transmembrane transport
chloride
monoatomic ion transport
potassium ion homeostasis
sodium ion homeostasis
sodium