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solute carrier family 18 member A2
Summary
- Gene Symbol
-
- SLC18A2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell projection
- Cytoplasmic vesicle
- Disease variant
- Disulfide bond
- Dystonia
- Glycoprotein
- Neurotransmitter transport
- Parkinsonism
- Phosphoprotein
- Reference proteome
- Synapse
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| Q05940 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| sequestering of neurotransmitter | ||
| response to toxic substance | ||
| serotonin uptake | ||
| histamine uptake | ||
| negative regulation of reactive oxygen species biosynthetic process |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| synaptic vesicle membrane | ||
| secretory granule membrane | ||
| membrane | ||
| terminal bouton | ||
| intracellular membrane-bounded organelle |
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| monoamine transmembrane transporter activity | ||
| serotonin:sodium:chloride symporter activity | ||
| monoamine:proton antiporter activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- transporter
- Functional Category
-
- E: Amino acid transport and metabolism
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| InterPro |
|---|
| MFS transporter superfamily |
| Major facilitator superfamily domain |
| Major facilitator superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0070490 | infantile parkinsonism-dystonia 2 | |
| DOID:14330 | Parkinson's disease | |
| DOID:1440 | Machado-Joseph disease | |
| DOID:2030 | anxiety disorder | |
| DOID:303 | substance-related disorder | |
| DOID:3602 | toxic encephalopathy | |
| DOID:670 | amphetamine abuse | |
| DOID:809 | cocaine abuse | |
| DOID:9744 | type 1 diabetes mellitus |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 25549 | RGD:3694 | RATNO20740 | ||
| 180837 | WB:WBGene00000295 | |||
| 214084 | MGI:106677 | MOUSE25238 | ||
| 282471 | BOVIN21633 | |||
| 379730 | Xenbase:XB-GENE-6254956 | |||
| 448192 | Xenbase:XB-GENE-940058 | |||
| 466213 | 9598_0:002ae6 | PANTR01638 | ||
| 486908 | CANLF11511 | |||
| 553304 | ZFIN:ZDB-GENE-080514-1 | DANRE13106 | ||
| 594935 | Xenbase:XB-GENE-5738585 |
