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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
solute carrier family 18 member A3
Summary
- Gene Symbol
-
- SLC18A3
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Congenital myasthenic syndrome
- Cytoplasmic vesicle
- Disease variant
- Glycoprotein
- Neurotransmitter transport
- Reference proteome
- Synapse
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| Q16572 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| serotonin uptake | ||
| acetylcholine uptake | ||
| positive regulation of acetylcholine secretion, neurotransmission | ||
| positive regulation of long-term synaptic potentiation | ||
| proton transmembrane transport |
GO Hierarchy
biological process
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
positive regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| synaptic vesicle membrane | ||
| terminal bouton | ||
| plasma membrane | ||
| clathrin-sculpted acetylcholine transport vesicle membrane | ||
| AP-2 adaptor complex |
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| acetylcholine:proton antiporter activity | ||
| acetylcholine transmembrane transporter activity | ||
| monoamine:proton antiporter activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- transporter
- Functional Category
-
- E: Amino acid transport and metabolism
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| InterPro |
|---|
| MFS transporter superfamily |
| Major facilitator superfamily domain |
| Major facilitator superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110672 | congenital myasthenic syndrome 21 | |
| DOID:10652 | Alzheimer's disease | |
| DOID:12858 | Huntington's disease | |
| DOID:2841 | asthma | |
| DOID:365 | bladder disease |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 20508 | MGI:1101061 | MOUSE13886 | ||
| 42795 | FB:FBgn0270928 | |||
| 60422 | RGD:62072 | |||
| 394082 | ZFIN:ZDB-GENE-040426-1410 | |||
| 445809 | CIOIN00637 | |||
| 466071 | 9598_0:002c28 | PANTR00598 | ||
| 486774 | CANLF11255 | |||
| 559347 | ZFIN:ZDB-GENE-060929-990 | |||
| 710053 | MACMU44800 | |||
| 780320 | Xenbase:XB-GENE-965085 |
