GlyCosmos Portal

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GO Term	Evidence Code	PMID
protein serine/threonine kinase activity	IDA	12065756
transmembrane receptor protein serine/threonine kinase activity	NAS	10051328
transmembrane signaling receptor activity	IDA	18184661
transforming growth factor beta receptor activity, type I	IBA
transforming growth factor beta receptor activity, type II	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

transmembrane receptor protein serine/threonine kinase activity

transforming growth factor beta receptor activity [inference]

activin receptor activity [inference]

BMP receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity

transforming growth factor beta receptor activity [inference]

activin receptor activity [inference]

BMP receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

transmembrane receptor protein serine/threonine kinase activity

transforming growth factor beta receptor activity [inference]

activin receptor activity [inference]

BMP receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity

transforming growth factor beta receptor activity [inference]

activin receptor activity [inference]

BMP receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

transmembrane receptor protein serine/threonine kinase activity

transforming growth factor beta receptor activity [inference]

activin receptor activity [inference]

BMP receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity

transforming growth factor beta receptor activity [inference]

activin receptor activity [inference]

BMP receptor activity

binding [inference]

protein binding

cytokine binding [inference]

BMP binding

SMAD binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity

transforming growth factor beta receptor activity [inference]

activin receptor activity [inference]

BMP receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

kinase

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ATP binding
nucleotide binding
transmembrane receptor protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase signaling pathway

Displaying **all 6** entries
InterPro
GS domain
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Ser/Thr protein kinase, TGFB receptor
Serine/threonine-protein kinase, active site

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0081237	acromesomelic dysplasia 3	Alliance of Genome Resources
DOID:0110965	brachydactyly type A2	Alliance of Genome Resources
DOID:0110978	brachydactyly type A1D	Alliance of Genome Resources
DOID:2256	osteochondrodysplasia	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of **102** in total

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Species	Gene ID	Orthologous MAtrix
Canis lupus familiaris	478484	CANLF13082
Macaca mulatta	705474	MACMU36513
Monodelphis domestica	100016370	MONDO25650
Equus caballus	100053554	HORSE30408
Ornithorhynchus anatinus	100086574	ORNAN03639
Danio rerio	100149664	DANRE01637
Taeniopygia guttata	100218713	TAEGU24294
Oryctolagus cuniculus	100351275	RABIT05215
Callithrix jacchus	100397724	CALJA28645
Pongo abelii	100444576	PONAB27896

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Acknowledgements