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phosphatase and actin regulator 4

Summary

Gene Symbol

PHACTR4

Organism

Homo sapiens (human)

External Links

NCBI Gene

65979

PubChem

65979

Alliance of Genome Resources

HGNC:25793

Annotation

Keyword

Actin-binding
Alternative splicing
Cell projection
Cytoplasm
Developmental protein
Neurogenesis
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IZ21

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
neural crest cell migration	ISS
neural crest cell migration	IBA
neural tube closure	ISS
Rho protein signal transduction	ISS
actin cytoskeleton organization	ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

actin filament-based process [inference]

actin cytoskeleton organization

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesenchymal cell migration [inference]

neural crest cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

developmental process [inference]

anatomical structure morphogenesis [inference]

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of an epithelial sheet [inference]

closure of optic fissure

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

anatomical structure development [inference]

system development [inference]

enteric nervous system development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

negative regulation of integrin-mediated signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of integrin-mediated signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of integrin-mediated signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of integrin-mediated signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of integrin-mediated signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

negative regulation of integrin-mediated signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of integrin-mediated signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

negative regulation of integrin-mediated signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of integrin-mediated signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of integrin-mediated signaling pathway

regulation of cell cycle

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytoplasm	IEA
lamellipodium	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

Displaying **all 4** entries
GO Term	Evidence Code	PMID
actin binding	ISS
actin binding	IBA
protein phosphatase 1 binding	ISS
protein phosphatase activator activity	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

actin binding

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding [inference]

protein phosphatase 1 binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity

phosphatase regulator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity

protein phosphatase regulator activity [inference]

protein phosphatase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Phosphatase and actin regulator

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
actin binding
actin cytoskeleton organization

Displaying 1 entry
InterPro
RPEL repeat

Ortholog

Displaying entries **11 - 20** of 78 in total

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Species	Gene ID	Orthologous MAtrix
Macaca mulatta	716990	MACMU23592
Equus caballus	100070745	HORSE28989
Pongo abelii	100172574	PONAB19456
Taeniopygia guttata	100224688	TAEGU13714
Oryctolagus cuniculus	100341279	RABIT04196
Callithrix jacchus	100398370	CALJA41116
Ailuropoda melanoleuca	100480469	AILME18793
Monodelphis domestica	100616921	MONDO23275
Sus scrofa	100621177	PIGXX29434
Loxodonta africana	100677476	LOXAF09073