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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
smoothened, frizzled class receptor
Summary
- Gene Symbol
-
- SMO
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Cell membrane
- Cell projection
- Developmental protein
- Disease variant
- Disulfide bond
- G-protein coupled receptor
- Glycoprotein
- Phosphoprotein
- Reference proteome
- Signal
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| Q99835 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of hair follicle development | ||
| anterior/posterior pattern specification | ||
| dorsal/ventral neural tube patterning | ||
| smoothened signaling pathway | ||
| negative regulation of protein phosphorylation |
GO Hierarchy
biological process
cellular process [inference]
developmental process [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of cell population proliferation [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
regulation of cellular localization [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| Golgi apparatus | ||
| ciliary tip | ||
| late endosome | ||
| endocytic vesicle membrane | ||
| intracellular membrane-bounded organelle |
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| cAMP-dependent protein kinase inhibitor activity | ||
| oxysterol binding | ||
| patched binding | ||
| protein sequestering activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- smoothened
- Functional Category
-
- G: Carbohydrate transport and metabolism
- I: Lipid transport and metabolism
- T: Signal transduction mechanisms
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050338 | primary bacterial infectious disease | |
| DOID:0050902 | medulloblastoma | |
| DOID:0060071 | pre-malignant neoplasm | |
| DOID:10534 | stomach cancer | |
| DOID:11832 | visual epilepsy | |
| DOID:1793 | pancreatic cancer | |
| DOID:219 | colon cancer | |
| DOID:2512 | nevoid basal cell carcinoma syndrome | |
| DOID:2513 | basal cell carcinoma | |
| DOID:3525 | middle cerebral artery infarction |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 25273 | RGD:3726 | RATNO29746 | ||
| 30225 | ZFIN:ZDB-GENE-980526-89 | DANRE33617 | ||
| 33196 | FB:FBgn0003444 | |||
| 319757 | MGI:108075 | MOUSE50165 | ||
| 398216 | Xenbase:XB-GENE-17333650 | |||
| 463718 | 9598_0:00234a | PANTR41387 | ||
| 539308 | BOVIN28409 | |||
| 701334 | MACMU30995 | |||
| 100015195 | MONDO34987 | |||
| 100078770 | ORNAN01136 |
