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sialic acid binding Ig like lectin 1

Summary

Gene Symbol

SIGLEC1

Aliases

CD169
FLJ00051
FLJ00055
FLJ00073
FLJ32150
SIGLEC-1
dJ1009E24.1
sialoadhesin

Organism

Homo sapiens (human)

External Links

NCBI Gene

6614

HGNC

11127

KEGG Gene ID

hsa:6614

PubChem

6614

Alliance of Genome Resources

HGNC:11127

Annotation

Keyword

Alternative splicing
Cell adhesion
Cell membrane
Disulfide bond
Endocytosis
Glycoprotein
Immunoglobulin domain
Lectin
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9BZZ2	Sialic acid-binding Ig-like lectin 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cell-cell adhesion		11133773
negative regulation of type I interferon production	IDA	26358190
inflammatory response		11133773
clathrin-dependent endocytosis of virus by host cell	IBA
cell-matrix adhesion		11133773

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

cell-cell adhesion

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell [inference]

clathrin-dependent endocytosis of virus by host cell

clathrin-dependent endocytosis [inference]

clathrin-dependent endocytosis of virus by host cell

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell [inference]

clathrin-dependent endocytosis of virus by host cell

viral process [inference]

transport of virus [inference]

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell [inference]

clathrin-dependent endocytosis of virus by host cell

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell [inference]

clathrin-dependent endocytosis of virus by host cell

clathrin-dependent endocytosis [inference]

clathrin-dependent endocytosis of virus by host cell

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell [inference]

clathrin-dependent endocytosis of virus by host cell

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell [inference]

clathrin-dependent endocytosis of virus by host cell

clathrin-dependent endocytosis [inference]

clathrin-dependent endocytosis of virus by host cell

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell [inference]

clathrin-dependent endocytosis of virus by host cell

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of type I interferon production [inference]

negative regulation of type I interferon production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of type I interferon production [inference]

negative regulation of type I interferon production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of type I interferon production [inference]

negative regulation of type I interferon production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of type I interferon production [inference]

negative regulation of type I interferon production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of type I interferon production [inference]

negative regulation of type I interferon production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
plasma membrane	IBA IDA	28129379
membrane		11133773
early endosome	IBA
late endosome	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
carbohydrate binding		11133773
virion binding	IBA

GO Hierarchy

molecular function

binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000088827

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

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Summary

External Links

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