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fascin actin-bundling protein 1

Summary

Gene Symbol

FSCN1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6624

PubChem

6624

Alliance of Genome Resources

HGNC:11148

Annotation

Keyword

3D-structure
Acetylation
Actin-binding
Cell junction
Cell projection
Cytoskeleton
Direct protein sequencing
Isopeptide bond
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A384MEG1
Q16658	55 kDa actin-bundling protein Singed-like protein p55
B3KTA3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
cell-cell junction assembly	IDA	9571235
establishment or maintenance of cell polarity	IBA
positive regulation of lamellipodium assembly	IDA	9571235
cell migration	IMP	20393565
cell migration	IBA

GO Hierarchy

biological process

cellular process [inference]

establishment or maintenance of cell polarity

establishment of cell polarity [inference]

establishment of monopolar cell polarity [inference]

establishment of apical/basal cell polarity

establishment or maintenance of bipolar cell polarity [inference]

establishment or maintenance of apical/basal cell polarity [inference]

establishment of apical/basal cell polarity

establishment or maintenance of monopolar cell polarity [inference]

establishment of monopolar cell polarity [inference]

establishment of apical/basal cell polarity

actin filament-based process [inference]

actin cytoskeleton organization

cell motility

cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

microspike assembly

cell junction assembly [inference]

cell-cell junction assembly

actin filament bundle assembly

parallel actin filament bundle assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

microspike assembly

plasma membrane bounded cell projection organization [inference]

plasma membrane bounded cell projection assembly [inference]

microspike assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly

cell-cell junction organization [inference]

cell-cell junction assembly

supramolecular fiber organization [inference]

actin filament organization [inference]

actin filament bundle organization [inference]

actin filament bundle assembly

parallel actin filament bundle assembly

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium organization [inference]

positive regulation of lamellipodium assembly

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix disassembly

regulation of cellular process [inference]

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

regulation of podosome assembly [inference]

positive regulation of podosome assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of lamellipodium assembly [inference]

positive regulation of lamellipodium assembly

regulation of microvillus assembly

regulation of filopodium assembly [inference]

positive regulation of filopodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

regulation of organelle assembly [inference]

regulation of podosome assembly [inference]

positive regulation of podosome assembly

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium organization [inference]

positive regulation of lamellipodium assembly

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix disassembly

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium organization [inference]

positive regulation of lamellipodium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of lamellipodium assembly [inference]

positive regulation of lamellipodium assembly

regulation of microvillus assembly

regulation of filopodium assembly [inference]

positive regulation of filopodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of microvillus organization [inference]

regulation of microvillus assembly

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of lamellipodium assembly [inference]

positive regulation of lamellipodium assembly

regulation of microvillus assembly

regulation of filopodium assembly [inference]

positive regulation of filopodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

regulation of lamellipodium organization [inference]

regulation of lamellipodium assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of lamellipodium organization [inference]

positive regulation of lamellipodium assembly

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

regulation of organelle assembly [inference]

regulation of podosome assembly [inference]

positive regulation of podosome assembly

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

regulation of podosome assembly [inference]

positive regulation of podosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium organization [inference]

positive regulation of lamellipodium assembly

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix disassembly

regulation of extracellular matrix organization [inference]

regulation of extracellular matrix disassembly [inference]

positive regulation of extracellular matrix disassembly

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix disassembly

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
stress fiber	IDA	3525578
ruffle	IDA	3525578
ruffle	IBA
podosome	IDA	20137952
cytoplasm	IDA	9571235

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

cell cortex

cytosol

membrane [inference]

plasma membrane region [inference]

cell projection membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction

site of polarized growth [inference]

growth cone

actin filament bundle [inference]

contractile actin filament bundle [inference]

stress fiber

actomyosin [inference]

stress fiber

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

podosome

cytoskeleton

actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

podosome

cytoskeleton

actin cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
RNA binding	HDA	22658674
actin binding	IDA	20393565 8999969
protein binding	IPI	15161933 20603015 21706053
protein-macromolecule adaptor activity	IEA
cadherin binding	HDA	25468996

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

actin filament binding

cell adhesion molecule binding [inference]

cadherin binding

protein-containing complex binding [inference]

actin filament binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

fascin

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
actin binding
actin filament binding
actin filament organization
cell migration
protein-macromolecule adaptor activity

Displaying **all 4** entries
InterPro
Actin-crosslinking
Fascin domain
Fascin, metazoans
Fascin

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6624	Xenbase:XB-GENE-488979
Mus musculus	14086	Xenbase:XB-GENE-488979	MOUSE46992
Pan troglodytes	463247		PANTR39649
Canis lupus familiaris	489880		CANLF16298
Bos taurus	507342		BOVIN21001
Danio rerio	558271		DANRE31370
Rattus norvegicus	683788		RATNO06035
Monodelphis domestica	100011390		MONDO31001
Ornithorhynchus anatinus	100081685		ORNAN15243
Taeniopygia guttata	100190193		TAEGU05052