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SOS Ras/Rac guanine nucleotide exchange factor 1

Summary

Gene Symbol

SOS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6654

PubChem

6654

Alliance of Genome Resources

HGNC:11187

Annotation

Keyword

3D-structure
Alternative splicing
Disease variant
Guanine-nucleotide releasing factor
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q07889

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 34 in total

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GO Term	Evidence Code	PMID
response to ischemia	IEA
eyelid development in camera-type eye	IEA
myelination	IEA
leukocyte migration	TAS
Schwann cell development	IEA

GO Hierarchy

biological process

immune system process [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

B cell homeostasis

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation

leukocyte migration

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation

signal transduction

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

cytokine-mediated signaling pathway

neurotrophin signaling pathway [inference]

neurotrophin TRK receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

ensheathment of neurons [inference]

axon ensheathment [inference]

myelination

cellular process involved in reproduction in multicellular organism [inference]

vitellogenesis

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

Schwann cell development

cell motility [inference]

cell migration [inference]

leukocyte migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cytoplasm organization [inference]

vitellogenesis

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

vitellogenesis

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation

molting cycle process [inference]

hair cycle process [inference]

hair follicle development

multicellular organism growth

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

B cell homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

cardiac chamber morphogenesis [inference]

cardiac atrium morphogenesis

tube morphogenesis [inference]

blood vessel morphogenesis

embryonic morphogenesis [inference]

pericardium morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of an epithelial sheet [inference]

pericardium morphogenesis

trabecula morphogenesis [inference]

heart trabecula morphogenesis

midbrain morphogenesis

anatomical structure development [inference]

hair follicle development

cell development [inference]

glial cell development [inference]

Schwann cell development

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

Schwann cell development

growth [inference]

developmental growth [inference]

multicellular organism growth

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

B cell homeostasis

response to stimulus [inference]

response to stress [inference]

response to ischemia

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

regulation of hematopoietic progenitor cell differentiation [inference]

regulation of lymphoid progenitor cell differentiation [inference]

regulation of pro-B cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

regulation of cellular process [inference]

signal transduction

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

B cell receptor signaling pathway

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

cytokine-mediated signaling pathway

neurotrophin signaling pathway [inference]

neurotrophin TRK receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cell population proliferation

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

regulation of hematopoietic progenitor cell differentiation [inference]

regulation of lymphoid progenitor cell differentiation [inference]

regulation of pro-B cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

regulation of T cell differentiation in thymus

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GO Term	Evidence Code	PMID
postsynaptic density	IEA
neuronal cell body	IEA
plasma membrane	IBA TAS
GTPase complex	IPI	25695162
cytosol	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

GTPase complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

organelle [inference]

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

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GO Term	Evidence Code	PMID
GTPase activator activity	TAS	9790532
protein binding	IPI	10026169 10206341 12029088 12482578 12577067 12628188 14679214 15507210 16520382 17084389 17141806 17474147 17515907 18454158 19141281 19323566 19380743 19464300 20133692 20473329 21706016 21988832 23397142 25241761 26005835 28514442 30631038 31980649 32296183 33961781 34591642 7527391 7629138 7773779 9020117 9447984 9544989 9569023 9690470
SH3 domain binding	IEA
epidermal growth factor receptor binding	IEA
protein heterodimerization activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

growth factor receptor binding [inference]

epidermal growth factor receptor binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

protein domain specific binding [inference]

SH3 domain binding

protein dimerization activity [inference]

protein heterodimerization activity

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

molecular condensate scaffold activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

guanine nucleotide exchange factor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
Ras protein signal transduction
small GTPase-mediated signal transduction

Displaying **all 5** entries
InterPro
Ras guanine nucleotide exchange factor domain superfamily
Ras guanine-nucleotide exchange factor, catalytic domain superfamily
Ras guanine-nucleotide exchange factors catalytic domain
Ras-like guanine nucleotide exchange factor, N-terminal
Ras-like guanine nucleotide exchange factor

Disease

Disease Ontology

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:0060466	gingival fibromatosis	Alliance of Genome Resources
DOID:0060582	Noonan syndrome 4	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:1882	atrial heart septal defect	Alliance of Genome Resources
DOID:2316	brain ischemia	Alliance of Genome Resources
DOID:3490	Noonan syndrome	Alliance of Genome Resources
DOID:3526	cerebral infarction	Alliance of Genome Resources
DOID:4362	cervical cancer	Alliance of Genome Resources
DOID:6420	pulmonary valve stenosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 86 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	20662		MGI:98354	MOUSE22186
Drosophila melanogaster	34790		FB:FBgn0001965
Caenorhabditis elegans	178846		WB:WBGene00004947
Rattus norvegicus	313845		RGD:1310949	RATNO35570
Pan troglodytes	459171	9598_0:000b3c		PANTR27462
Bos taurus	537682			BOVIN02276
Danio rerio	556286		ZFIN:ZDB-GENE-070209-128
Macaca mulatta	713777			MACMU08488
Saccharomyces cerevisiae S288C	851019		SGD:S000004301
Ornithorhynchus anatinus	100078989			ORNAN12543

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Last updated: December 9, 2024