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SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1

Summary

Gene Symbol

SPOCK1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6695

PubChem

6695

Alliance of Genome Resources

HGNC:11251

Annotation

Keyword

Direct protein sequencing
Disulfide bond
Extracellular matrix
Heparan sulfate
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q08629	Protein SPOCK

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
negative regulation of cell-substrate adhesion	IDA	12853036
neuron migration	ISS
negative regulation of endopeptidase activity	IDA	14511383
nervous system development	NAS	9181134
regulation of cell growth	NAS	8389704

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

neuron differentiation [inference]

central nervous system neuron differentiation

cell motility [inference]

cell migration [inference]

neuron migration

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

neuron differentiation [inference]

central nervous system neuron differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of growth [inference]

regulation of cell growth

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of cellular process [inference]

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

regulation of cell-substrate adhesion [inference]

negative regulation of cell-substrate adhesion

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of cellular component organization [inference]

regulation of cell growth

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
postsynaptic density	NAS	9181134
neuromuscular junction	ISS
sarcoplasm	ISS
node of Ranvier	ISS
extracellular space	IDA	14511383

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

cytoplasm

sarcoplasm

cell junction [inference]

synapse [inference]

neuromuscular junction

node of Ranvier

organelle [inference]

postsynaptic specialization [inference]

postsynaptic density

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183
cysteine-type endopeptidase inhibitor activity	IDA	14511383
metalloendopeptidase inhibitor activity	IDA	11751414
serine-type endopeptidase inhibitor activity	NAS	14511383
calcium ion binding	IDA	9323035

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

insulin-like growth factor-binding protein 5

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
calcium ion binding
collagen binding
extracellular matrix binding

Displaying **all 4** entries
InterPro
EF-hand domain pair
SPARC/Testican, calcium-binding domain
Thyroglobulin type-1 superfamily
Thyroglobulin type-1

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 58 in total

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Species	Gene ID	Orthologous MAtrix
Chrysemys picta bellii	101941552	CHRPI29344
Chinchilla lanigera	102003518	CHILA02381
Haplochromis burtoni	102314500	HAPBU21046
Poecilia formosa	103135479	POEFO03908
Callorhinchus milii	103183716	CALMI28209
Carlito syrichta	103265871	CARSF08781
Cynoglossus semilaevis	103390900	CYNSE09610
Poecilia reticulata	103471320	POERE02700
Ursus maritimus	103663950	URSMA04862
Nannospalax galili	103733054	NANGA07696